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J. Biol. Chem., Vol. 269, Issue 12, 8749-8753, 03, 1994
P Bergsten, E Grapengiesser, E Gylfe, A Tengholm and B Hellman
The cytoplasmic Ca2+ concentration ([Ca2+]i) was measured in single
pancreatic mouse islets superfused in a system allowing concomitant
recordings of insulin release. When glucose was raised from 3 to 11 mM,
[Ca2+]i responded by a transient lowering followed by a rise to an average
level of 192 +/- 11 nM. In 77% of the islets the rise was associated with
the gradual appearance of oscillations, which were either fast (2-7/min),
slow (0.3-0.9/min), or a combination of both types. The characteristics of
the fast [Ca2+]i oscillations were those expected from a relationship with
the electrical burst activity in islets. Accordingly, in most cases the
fast oscillations were remarkably regular. The slow [Ca2+]i oscillations
had characteristics similar to the large amplitude ones in individual
beta-cells. Whereas glucagon and dibutyryl cAMP could transform slow islet
oscillations into fast ones, the alpha 2-adrenergic agonist clonidine had
the opposite effect. The rapid islet oscillations were also facilitated by
elevated concentrations of extracellular Ca2+. Reinforcing the arguments
for [Ca2+]i oscillations as responsible for a pulsatile insulin secretion
it was possible to demonstrate that the release of the hormone from single
islets is synchronized with the slow [Ca2+]i oscillations.
Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic islets
Department of Medical Cell Biology, Uppsala University, Sweden.
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