| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 27, 17772-17775, Jul, 1994
DJ Thuerauf, DS Hanford and CC Glembotski
GATA-binding proteins are transcription factors that regulate the stage-
and tissue-specific expression of globin genes in cells of the erythroid
lineage. Recently, a cardiac GATA-binding protein was found to be the
earliest gene expressed during cardiogenesis; however, the target genes of
this transcription factor in the heart are unknown. Since brain natriuretic
peptide (BNP) is activated early in cardiac growth and development, we
evaluated whether it could serve as a target gene for GATA-binding
protein-mediated induction. Upon isolating and sequencing 2.5 kilobases of
the rat BNP 5'-flanking sequence (FS), a variety of putative
transcriptional enhancer sites were identified, including several GATA
consensus sequences (WGATAR), one of which apparently serves as the major
promoter site. Primary myocardial cells were transfected with
BNP/luciferase fusion genes; reporter expression was strongly induced by
typical growth factors such as phorbol esters, serum, or alpha 1-adrenergic
agonists, as well as by GATA-4 overexpression. Truncation analyses showed
that inducibility mapped primarily to the proximal -116 base pair of the
rat BNP 5'-FS, where there are two consensus GATA sites in addition to the
GATA sequence at the TATA box. Point mutation analyses showed that at least
one of the GATA sites was required to confer full GATA-4-inducible
transcription. These results demonstrate that a proximal region of the rat
BNP 5'-FS is required for growth factor- and GATA-inducible transcription,
supporting the view that the BNP gene could serve as a target for GATA-
binding proteins during early cardiac development.
Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression
Department of Biology, San Diego State University, California 92182.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Bingham, L. Ooi, L. Kozera, E. White, and I. C. Wood The Repressor Element 1-Silencing Transcription Factor Regulates Heart-Specific Gene Expression Using Multiple Chromatin-Modifying Complexes Mol. Cell. Biol., June 1, 2007; 27(11): 4082 - 4092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Balza Jr. and R. P. Misra Role of the Serum Response Factor in Regulating Contractile Apparatus Gene Expression and Sarcomeric Integrity in Cardiomyocytes J. Biol. Chem., March 10, 2006; 281(10): 6498 - 6510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho GATA transcription factors in the developing and adult heart Cardiovasc Res, August 1, 2004; 63(2): 196 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Antos, T. A. McKinsey, M. Dreitz, L. M. Hollingsworth, C.-L. Zhang, K. Schreiber, H. Rindt, R. J. Gorczynski, and E. N. Olson Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors J. Biol. Chem., August 1, 2003; 278(31): 28930 - 28937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. He, M. Mendez, and M. C. LaPointe Regulation of the human brain natriuretic peptide gene by GATA-4 Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E50 - E57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Dai, P. Cserjesi, B. E. Markham, and J. D. Molkentin The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism J. Biol. Chem., June 28, 2002; 277(27): 24390 - 24398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kerkela, S. Pikkarainen, T. Majalahti-Palviainen, H. Tokola, and H. Ruskoaho Distinct Roles of Mitogen-activated Protein Kinase Pathways in GATA-4 Transcription Factor-mediated Regulation of B-type Natriuretic Peptide Gene J. Biol. Chem., April 12, 2002; 277(16): 13752 - 13760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ogawa, Y. Saito, K. Kuwahara, M. Harada, Y. Miyamoto, I. Hamanaka, N. Kajiyama, N. Takahashi, T. Izumi, R. Kawakami, et al. Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression Cardiovasc Res, February 1, 2002; 53(2): 451 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liang, R. J. Wiese, O. F. Bueno, Y.-S. Dai, B. E. Markham, and J. D. Molkentin The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes Mol. Cell. Biol., November 1, 2001; 21(21): 7460 - 7469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Marttila, N. Hautala, P. Paradis, M. Toth, O. Vuolteenaho, M. Nemer, and H. Ruskoaho GATA4 Mediates Activation of the B-Type Natriuretic Peptide Gene Expression in Response to Hemodynamic Stress Endocrinology, November 1, 2001; 142(11): 4693 - 4700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Aihara, M. Kurabayashi, Y. Saito, Y. Ohyama, T. Tanaka, S.-i. Takeda, K. Tomaru, K.-i. Sekiguchi, M. Arai, T. Nakamura, et al. Cardiac Ankyrin Repeat Protein Is a Novel Marker of Cardiac Hypertrophy : Role of M-CAT Element Within the Promoter Hypertension, July 1, 2000; 36(1): 48 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lin, S. Aggarwal, T. W. Glover, M. B. Orringer, S. Hanash, and D. G. Beer A Minimal Critical Region of the 8p22-23 Amplicon in Esophageal Adenocarcinomas Defined Using Sequence Tagged Site-Amplification Mapping and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene Cancer Res., March 1, 2000; 60(5): 1341 - 1347. [Abstract] [Full Text]
|
|
|
|
|
|
T. Majalahti-Palviainen, M. Hirvinen, V. Tervonen, M. Ilves, H. Ruskoaho, and O. Vuolteenaho Gene Structure of a New Cardiac Peptide Hormone: A Model for Heart-Specific Gene Expression Endocrinology, February 1, 2000; 141(2): 731 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Vyas, J. J. McCarthy, and R. W. Tsika Nuclear Protein Binding at the beta -Myosin Heavy Chain A/T-rich Element Is Enriched following Increased Skeletal Muscle Activity J. Biol. Chem., October 22, 1999; 274(43): 30832 - 30842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Tevosian, A. E. Deconinck, A. B. Cantor, H. I. Rieff, Y. Fujiwara, G. Corfas, and S. H. Orkin FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped PNAS, February 2, 1999; 96(3): 950 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Svensson, R. L. Tufts, C. E. Polk, and J. M. Leiden Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes PNAS, February 2, 1999; 96(3): 956 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development, January 1, 1999; 126(1): 75 - 84. [Abstract] [PDF]
|
|
|
|
|
|
I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Wang, W. Nikovits Jr., M. Schleinitz, and F. E. Stockdale A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis Mol. Cell. Biol., October 1, 1998; 18(10): 6023 - 6034. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Sepulveda, N. Belaguli, V. Nigam, C.-Y. Chen, M. Nemer, and R. J. Schwartz GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression Mol. Cell. Biol., June 1, 1998; 18(6): 3405 - 3415. [Abstract] [Full Text]
|
|
|
|
|
|
M. L. Rosoff and N. M. Nathanson GATA Factor-dependent Regulation of Cardiac m2 Muscarinic Acetylcholine Gene Transcription J. Biol. Chem., April 10, 1998; 273(15): 9124 - 9129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Gallagher and B. G. Forget An Alternate Promoter Directs Expression of a Truncated, Muscle-specific Isoform of the Human Ankyrin 1 Gene J. Biol. Chem., January 16, 1998; 273(3): 1339 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Magga, O. Vuolteenaho, H. Tokola, M. Marttila, and H. Ruskoaho Involvement of Transcriptional and Posttranscriptional Mechanisms in Cardiac Overload–Induced Increase of B-Type Natriuretic Peptide Gene Expression Circ. Res., November 19, 1997; 81(5): 694 - 702. [Abstract] [Full Text]
|
|
|
|
|
|
C.-Z. He and J. B. E. Burch The Chicken GATA-6 Locus Contains Multiple Control Regions That Confer Distinct Patterns of Heart Region-specific Expression in Transgenic Mouse Embryos J. Biol. Chem., November 7, 1997; 272(45): 28550 - 28556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zechner, D. J. Thuerauf, D. S. Hanford, P. M. McDonough, and C. C. Glembotski A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression J. Cell Biol., October 6, 1997; 139(1): 115 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Herzig, S. M. Jobe, H. Aoki, J. D. Molkentin, A. W. Cowley Jr., S. Izumo, and B. E. Markham Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload PNAS, July 8, 1997; 94(14): 7543 - 7548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J D Molkentin, Q Lin, S A Duncan, and E N Olson Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes & Dev., April 15, 1997; 11(8): 1061 - 1072. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Thuerauf and C. C. Glembotski Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element J. Biol. Chem., March 14, 1997; 272(11): 7464 - 7472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Narita, M Bielinska, and D. Wilson Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells Development, January 10, 1997; 124(19): 3755 - 3764. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Mably and C.-C. Liew Factors Involved in Cardiogenesis and the Regulation of Cardiac-Specific Gene Expression Circ. Res., July 1, 1996; 79(1): 4 - 13. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. LaPointe, G. Wu, M. Garami, X.-P. Yang, and D. G. Gardner Tissue-Specific Expression of the Human Brain Natriuretic Peptide Gene in Cardiac Myocytes Hypertension, March 1, 1996; 27(3): 715 - 722. [Abstract] [Full Text]
|
|
|
|
|
|
C Soudais, M Bielinska, M Heikinheimo, C. MacArthur, N Narita, J. Saffitz, M. Simon, J. Leiden, and D. Wilson Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro Development, January 11, 1995; 121(11): 3877 - 3888. [Abstract] [PDF]
|
|
|
|
|
|
A. Murat, C. Pellieux, H.-R. Brunner, and T. Pedrazzini Calcineurin Blockade Prevents Cardiac Mitogen-activated Protein Kinase Activation and Hypertrophy in Renovascular Hypertension J. Biol. Chem., December 22, 2000; 275(52): 40867 - 40873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liang, L. J. De Windt, S. A. Witt, T. R. Kimball, B. E. Markham, and J. D. Molkentin The Transcription Factors GATA4 and GATA6 Regulate Cardiomyocyte Hypertrophy in Vitro and in Vivo J. Biol. Chem., August 3, 2001; 276(32): 30245 - 30253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Molkentin The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6. UBIQUITOUSLY EXPRESSED REGULATORS OF TISSUE-SPECIFIC GENE EXPRESSION J. Biol. Chem., December 8, 2000; 275(50): 38949 - 38952. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
