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J. Biol. Chem., Vol. 269, Issue 27, 17833-17840, 07, 1994
H Ohmori, AF Dohrman, M Gallup, T Tsuda, H Kai, JR Gum Jr, YS Kim and CB Basbaum
To obtain cDNAs for analysis of mucin gene transcription in rat models of
human disease, we screened a rat intestinal cDNA library in lambda ZAPII
using an upstream non-tandem repeat cDNA fragment of the human MUC 2 gene
(Gum, J., Hicks, J., Toribara, N., Rothe, E., Lagace, R., and Y., K. (1992)
J. Biol. Chem. 267, 21375-21383). Three cDNAs, 1-1, 8- 1, and 21-1, were
isolated. A translation start site was found in cDNA 21-1. Combined
nucleotide sequence for the three cDNAs contained an open reading frame
spanning 4546 base pairs. This amino-terminal sequence contains a
non-tandem repeat domain enriched in cysteine (1391 residues) followed by
an irregular tandem repeat domain (122 residues). Identity with the human
gene is about 80% in the non-tandem repeat domain and about 38% in the
irregular tandem repeat domain. Primer extension and S1 nuclease protection
analysis indicate a transcription start site at 28 base pairs upstream of
translation initiation. Northern analysis showed expression of cognate RNA
in the intestine and airway but not heart and spleen. The cDNAs have been
used to isolate the gene promoter, the structure of which should yield
clues to the regulation of mucin expression in rat models of human disease.
Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway
Department of Anatomy, University of California, San Francisco 94143.
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