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J. Biol. Chem., Vol. 269, Issue 28, 18401-18407, 07, 1994
A Ullrich, I Sures, M D'Egidio, B Jallal, TJ Powell, R Herbst, A Dreps, M Azam, M Rubinstein and C Natoli
Immunization of mice with conditioned media from human breast cancer cells
yielded the monoclonal antibody SP-2, which recognized an antigen of
approximately 90-95 kDa. This protein, designated 90K, was found to be
present in the serum of healthy individuals and at elevated levels in the
serum of subpopulations of patients with various types of cancer and AIDS.
Here we report the primary structure of the SP-2 antigen and demonstrate
its relationship to a family of proteins which carry a scavenger receptor
cysteine-rich domain. Northern blot analysis of normal tissues, primary
tumors, and tumor-derived cell lines indicates a broad expression spectrum
of the 90K gene at widely varying levels. Functional characterization
reveals stimulatory effects of 90K on host defense systems, such as natural
killer cell and lymphokine-activated killer cell activity, and indicates
that its immunostimulatory effects may be mediated through the induction of
interleukin-2 and possibly other cytokines.
The secreted tumor-associated antigen 90K is a potent immune stimulator
Department of Molecular Biology, Max-Planck-Institut fur Biochemie, Martinsried, Federal Republic of Germany.
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