| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 34, 21614-21619, 08, 1994
MD Ledesma, P Bonay, C Colaco and J Avila
Alzheimer's disease is typified by the characteristic histopathological
lesions of neurofibrillar plaques and tangles. The latter are composed of
paired helical filaments (PHFs), the major components of which are modified
forms of the microtubule-associated protein tau. The exact nature of these
modifications remains unknown, although the presence of hyperphosphorylated
tau in PHFs argues strongly that phosphorylation is one of the
modifications that result in the polymerization of tau into PHFs. However,
hyperphosphorylation alone is insufficient to explain the formation of
PHFs. In an attempt to characterize other post- translational modifications
of PHF-tau, we have analyzed its glycation. A fraction of PHF-tau seems to
be glycated in vivo, whereas soluble tau from either Alzheimer's disease or
non-demented human brain is not glycated at all. Purified tau from bovine
brain can be efficiently glycated in vitro. Tau glycation is accompanied by
a decrease in the tau binding to tubulin. These results support the view
that glycation may be one of the modifications hampering the binding of tau
to tubulin in Alzheimer's disease, thus facilitating tau aggregation into
PHFs.
Analysis of microtubule-associated protein tau glycation in paired helical filaments
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, Spain.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Kuhla, C. Haase, K. Flach, H.-J. Luth, T. Arendt, and G. Munch Effect of Pseudophosphorylation and Cross-linking by Lipid Peroxidation and Advanced Glycation End Product Precursors on Tau Aggregation and Filament Formation J. Biol. Chem., March 9, 2007; 282(10): 6984 - 6991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sato, N. Shimogaito, X. Wu, S. Kikuchi, S.-i. Yamagishi, and M. Takeuchi Toxic Advanced Glycation End Products (TAGE) Theory in Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, May 1, 2006; 21(3): 197 - 208. [Abstract] [PDF]
|
|
|
|
 |
|
 L. A Boothby and P. L Doering Vitamin C and Vitamin E for Alzheimer's Disease Ann. Pharmacother., December 1, 2005; 39(12): 2073 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Arai, J.-P. Guo, and P. L. McGeer Proteolysis of Non-phosphorylated and Phosphorylated Tau by Thrombin J. Biol. Chem., February 18, 2005; 280(7): 5145 - 5153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Necula and J. Kuret Pseudophosphorylation and Glycation of Tau Protein Enhance but Do Not Trigger Fibrillization in Vitro J. Biol. Chem., November 26, 2004; 279(48): 49694 - 49703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Landino, T. E. Skreslet, and J. A. Alston Cysteine Oxidation of Tau and Microtubule-associated Protein-2 by Peroxynitrite: MODULATION OF MICROTUBULE ASSEMBLY KINETICS BY THE THIOREDOXIN REDUCTASE SYSTEM J. Biol. Chem., August 13, 2004; 279(33): 35101 - 35105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chen, M. A. Wollmer, F. Hoerndli, G. Munch, B. Kuhla, E. I. Rogaev, M. Tsolaki, A. Papassotiropoulos, and J. Gotz Role for glyoxalase I in Alzheimer's disease PNAS, May 18, 2004; 101(20): 7687 - 7692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. AVILA, J. J. LUCAS, M. PEREZ, and F. HERNANDEZ Role of Tau Protein in Both Physiological and Pathological Conditions Physiol Rev, April 1, 2004; 84(2): 361 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Horiguchi, K. Uryu, B. I. Giasson, H. Ischiropoulos, R. LightFoot, C. Bellmann, C. Richter-Landsberg, V. M.-Y. Lee, and J. Q. Trojanowski Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies Am. J. Pathol., September 1, 2003; 163(3): 1021 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, M. von Bergen, E.-M. Mandelkow, and E. Mandelkow Structure, Stability, and Aggregation of Paired Helical Filaments from Tau Protein and FTDP-17 Mutants Probed by Tryptophan Scanning Mutagenesis J. Biol. Chem., October 25, 2002; 277(44): 41390 - 41400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W STITT Advanced glycation: an important pathological event in diabetic and age related ocular disease Br. J. Ophthalmol., June 1, 2001; 85(6): 746 - 753. [Full Text] [PDF]
|
|
|
|
|
|
A. d. C. Alonso, T. Zaidi, M. Novak, I. Grundke-Iqbal, and K. Iqbal Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments PNAS, May 24, 2001; (2001) 121119298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grundman Vitamin E and Alzheimer disease: the basis for additional clinical trials1 Am. J. Clinical Nutrition, February 1, 2000; 71(2): 630s - 636s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Grundke-Iqbal and K. Iqbal Tau Pathology Generated by Overexpression of Tau Am. J. Pathol., December 1, 1999; 155(6): 1781 - 1785. [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Curb, B. L. Rodriguez, R. D. Abbott, H. Petrovitch, G. W. Ross, K. H. Masaki, D. Foley, P. L. Blanchette, T. Harris, R. Chen, et al. Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance Neurology, March 1, 1999; 52(5): 971 - 971. [Abstract] [Full Text]
|
|
|
|
|
|
N. Sasaki, R. Fukatsu, K. Tsuzuki, Y. Hayashi, T. Yoshida, N. Fujii, T. Koike, I. Wakayama, R. Yanagihara, R. Garruto, et al. Advanced Glycation End Products in Alzheimer's Disease and Other Neurodegenerative Diseases Am. J. Pathol., October 1, 1998; 153(4): 1149 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Canu, L. Dus, C. Barbato, M. T. Ciotti, C. Brancolini, A. M. Rinaldi, M. Novak, A. Cattaneo, A. Bradbury, and P. Calissano Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis J. Neurosci., September 15, 1998; 18(18): 7061 - 7074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Smith, L. M. Sayre, V. E. Anderson, P. L.R. Harris, M. F. Beal, N. Kowall, and G. Perry Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine J. Histochem. Cytochem., May 1, 1998; 46(6): 731 - 736. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. Yao and P. D. Coleman Reduction of O-Linked N-Acetylglucosamine-Modified Assembly Protein-3 in Alzheimer's Disease J. Neurosci., April 1, 1998; 18(7): 2399 - 2411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Smith, P. L. Richey Harris, L. M. Sayre, J. S. Beckman, and G. Perry Widespread Peroxynitrite-Mediated Damage in Alzheimer's Disease J. Neurosci., April 15, 1997; 17(8): 2653 - 2657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Arnold, G. V.W. Johnson, R. N. Cole, D. L.-Y. Dong, M. Lee, and G. W. Hart The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine J. Biol. Chem., November 15, 1996; 271(46): 28741 - 28744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ding and D. D. Vandré High Molecular Weight Microtubule-associated Proteins Contain O-Linked N-Acetylglucosamine J. Biol. Chem., May 24, 1996; 271(21): 12555 - 12561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. del C. Alonso, T. Zaidi, M. Novak, H. S. Barra, I. Grundke-Iqbal, and K. Iqbal Interaction of Tau Isoforms with Alzheimer's Disease Abnormally Hyperphosphorylated Tau and in Vitro Phosphorylation into the Disease-like Protein J. Biol. Chem., October 5, 2001; 276(41): 37967 - 37973. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
