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J. Biol. Chem., Vol. 269, Issue 39, 24020-24026, Sep, 1994
T Tanaka, J Nishida, K Mitani, S Ogawa, Y Yazaki and H Hirai
Evi-1 is a gene, encoding a zinc finger protein, associated with a common
viral integration site in murine leukemias. It is suggested that Evi-1
plays important roles in embryogenesis and transformation of myeloid cells.
To elucidate mechanisms by which Evi-1 induces such biological effects, we
analyzed the relationship between Evi-1 and AP-1 which could regulate
cellular proliferation and differentiation. When Evi-1 was expressed,
transactivation through a 12-O- tetradecanoylphorbol 13-acetate-responsive
element was observed in NIH3T3 and P19 cells. Evi-1-transfected P19 cells
showed some differentiated phenotypes and increased expression of
endogenous c-Jun and c-Fos. These results indicate that Evi-1 raises AP-1
activity. Evi- 1 caused stimulation of the c-fos promoter transactivation,
which seems to be a main mechanism of AP-1 activation, through at least two
portions of the promoter. Evi-1 has the first zinc finger domain at the N
terminus and the second zinc finger domain near the C-terminus. We
constructed deletion mutants of Evi-1 and investigated the functions of
these domains. It was shown that the second zinc finger domain is essential
for the activation of AP-1 and transactivation of the c-fos promoter.
Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain
Department of Molecular Biology, Jichi Medical School, Tochigi, Japan.
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