| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 4, 2361-2364, 01, 1994
KI Mitchelhill, D Stapleton, G Gao, C House, B Michell, F Katsis, LA Witters and BE Kemp
The AMP-activated protein kinase is responsible for the regulation of fatty
acid synthesis by phosphorylation of acetyl-CoA carboxylase. It may also
regulate cholesterol synthesis via phosphorylation and inactivation of
hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. We have
purified the AMP-activated protein kinase 14,000- fold from porcine liver.
The 63-kDa catalytic subunit co-purifies with two proteins of 40 and 38 kDa
that may function as subunits. Partial amino acid sequence of the 63-kDa
subunit revealed a striking homology with the catalytic domain of the yeast
protein kinase transcriptional regulator Snf1 and its plant homologs. The
Snf1 (72 kDa) and Snf4 (36 kDa) complex was also purified and found to
phosphorylate the AMP- activated protein kinase peptide substrate,
HMRSAMSGLHLVKRR-amide, but was not activated by AMP. Both Snf1/4 and the
AMP-activated protein kinase phosphorylate and inactivate yeast acetyl-CoA
carboxylase in vitro. These results indicate that during evolution the
catalytic domain sequences of the Snf1 protein kinase subfamily have been
exploited in the control of mammalian lipid metabolism and raise the
possibilities that the AMP-activated protein kinase may have other
substrates involved in regulating gene expression pathways, as well as Snf1
homologs participating in the control of lipid metabolism in many
eukaryotic organisms.
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Momcilovic, S. H. Iram, Y. Liu, and M. Carlson Roles of the Glycogen-binding Domain and Snf4 in Glucose Inhibition of SNF1 Protein Kinase J. Biol. Chem., July 11, 2008; 283(28): 19521 - 19529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Osler and J. R. Zierath Minireview: Adenosine 5'-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle Endocrinology, March 1, 2008; 149(3): 935 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-P. Hong and M. Carlson Regulation of Snf1 Protein Kinase in Response to Environmental Stress J. Biol. Chem., June 8, 2007; 282(23): 16838 - 16845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Arad, C. E. Seidman, and J.G. Seidman AMP-Activated Protein Kinase in the Heart: Role During Health and Disease Circ. Res., March 2, 2007; 100(4): 474 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pang, B. Xiong, J.-Y. Li, B.-Y. Qiu, G.-Z. Jin, J.-K. Shen, and J. Li Conserved {alpha}-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase {alpha} Subunits J. Biol. Chem., January 5, 2007; 282(1): 495 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. W. Dolinsky and J. R. B. Dyck Role of AMP-activated protein kinase in healthy and diseased hearts Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2557 - H2569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Proszkowiec-Weglarz, M. P. Richards, and J. P. McMurtry Molecular Cloning, Genomic Organization, and Expression of Three Chicken 5'-AMP-Activated Protein Kinase Gamma Subunit Genes. Poult. Sci., November 1, 2006; 85(11): 2031 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Fujii, N. Jessen, and L. J. Goodyear AMP-activated protein kinase and the regulation of glucose transport Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E867 - E877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Elbing, E. M. Rubenstein, R. R. McCartney, and M. C. Schmidt Subunits of the Snf1 Kinase Heterotrimer Show Interdependence for Association and Activity J. Biol. Chem., September 8, 2006; 281(36): 26170 - 26180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Momcilovic, S.-P. Hong, and M. Carlson Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro J. Biol. Chem., September 1, 2006; 281(35): 25336 - 25343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Hardie, S. A. Hawley, and J. W. Scott AMP-activated protein kinase - development of the energy sensor concept J. Physiol., July 1, 2006; 574(1): 7 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gregor, A. Zeold, S. Oehler, K. A. Marobela, P. Fuchs, G. Weigel, D. G. Hardie, and G. Wiche Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres J. Cell Sci., May 1, 2006; 119(9): 1864 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Suzuki, G.-i. Kusakai, Y. Shimojo, J. Chen, T. Ogura, M. Kobayashi, and H. Esumi Involvement of Transforming Growth Factor-{beta}1 Signaling in Hypoxia-induced Tolerance to Glucose Starvation J. Biol. Chem., September 9, 2005; 280(36): 31557 - 31563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Jessen and L. J. Goodyear Contraction signaling to glucose transport in skeletal muscle J Appl Physiol, July 1, 2005; 99(1): 330 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-P. Hong, M. Momcilovic, and M. Carlson Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase {alpha} as Snf1-activating Kinases in Yeast J. Biol. Chem., June 10, 2005; 280(23): 21804 - 21809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Iseli, M. Walter, B. J. W. van Denderen, F. Katsis, L. A. Witters, B. E. Kemp, B. J. Michell, and D. Stapleton AMP-activated Protein Kinase {beta} Subunit Tethers {alpha} and {gamma} Subunits via Its C-terminal Sequence (186-270) J. Biol. Chem., April 8, 2005; 280(14): 13395 - 13400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fraser, P. Mount, R. Hill, V. Levidiotis, F. Katsis, D. Stapleton, B. E. Kemp, and D. A. Power Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality Am J Physiol Renal Physiol, March 1, 2005; 288(3): F578 - F586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Legembre, R. Schickel, B. C. Barnhart, and M. E. Peter Identification of SNF1/AMP Kinase-related Kinase as an NF-{kappa}B-regulated Anti-apoptotic Kinase Involved in CD95-induced Motility and Invasiveness J. Biol. Chem., November 5, 2004; 279(45): 46742 - 46747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. McCrimmon, X. Fan, Y. Ding, W. Zhu, R. J. Jacob, and R. S. Sherwin Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus Diabetes, August 1, 2004; 53(8): 1953 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Suzuki, J. Lu, G.-i. Kusakai, A. Kishimoto, T. Ogura, and H. Esumi ARK5 Is a Tumor Invasion-Associated Factor Downstream of Akt Signaling Mol. Cell. Biol., April 15, 2004; 24(8): 3526 - 3535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yu, N. Fujii, M. F. Hirshman, J. M. Pomerleau, and L. J. Goodyear Cloning and characterization of mouse 5'-AMP-activated protein kinase {gamma}3 subunit Am J Physiol Cell Physiol, February 1, 2004; 286(2): C283 - C292. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Adams, Z.-P. Chen, B. J.W. Van Denderen, C. J. Morton, M. W. Parker, L. A. Witters, D. Stapleton, and B. E. Kemp Intrasteric control of AMPK via the {gamma}1 subunit AMP allosteric regulatory site Protein Sci., January 1, 2004; 13(1): 155 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Morrow, F. Foufelle, J. M. C. Connell, J. R. Petrie, G. W. Gould, and I. P. Salt Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells J. Biol. Chem., August 22, 2003; 278(34): 31629 - 31639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nagata, M. Mogi, and K. Walsh AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is Essential for Angiogenesis in Response to Hypoxic Stress J. Biol. Chem., August 15, 2003; 278(33): 31000 - 31006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-P. Hong, F. C. Leiper, A. Woods, D. Carling, and M. Carlson Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases PNAS, July 22, 2003; 100(15): 8839 - 8843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nath, R. R. McCartney, and M. C. Schmidt Purification and Characterization of Snf1 Kinase Complexes Containing a Defined beta Subunit Composition J. Biol. Chem., December 20, 2002; 277(52): 50403 - 50408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Zou, X.-Y. Hou, C.-M. Shi, D. Nagata, K. Walsh, and R. A. Cohen Modulation by Peroxynitrite of Akt- and AMP-activated Kinase-dependent Ser1179 Phosphorylation of Endothelial Nitric Oxide Synthase J. Biol. Chem., August 30, 2002; 277(36): 32552 - 32557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Quintero, M. Ohta, H. Shi, J.-K. Zhu, and J. M. Pardo Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis PNAS, June 25, 2002; 99(13): 9061 - 9066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu and Y.-Y. Yeh S-Alk(en)yl Cysteines of Garlic Inhibit Cholesterol Synthesis by Deactivating HMG-CoA Reductase in Cultured Rat Hepatocytes J. Nutr., June 1, 2002; 132(6): 1129 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Shirra, J. Patton-Vogt, A. Ulrich, O. Liuta-Tehlivets, S. D. Kohlwein, S. A. Henry, and K. M. Arndt Inhibition of Acetyl Coenzyme A Carboxylase Activity Restores Expression of the INO1 Gene in a snf1 Mutant Strain of Saccharomyces cerevisiae Mol. Cell. Biol., September 1, 2001; 21(17): 5710 - 5722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Leclerc, C. Lenzner, L. Gourdon, S. Vaulont, A. Kahn, and B. Viollet Hepatocyte Nuclear Factor-4{alpha} Involved in Type 1 Maturity-Onset Diabetes of the Young Is a Novel Target of AMP-Activated Protein Kinase Diabetes, July 1, 2001; 50(7): 1515 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Vincent, R. Townley, S. Kuchin, and M. Carlson Subcellular localization of the Snf1 kinase is regulated by specific {beta} subunits and a novel glucose signaling mechanism Genes & Dev., May 1, 2001; 15(9): 1104 - 1114. [Abstract] [Full Text]
|
|
|
|
 |
|
 J.-K. Zhu Genetic Analysis of Plant Salt Tolerance Using Arabidopsis Plant Physiology, November 1, 2000; 124(3): 941 - 948. [Full Text]
|
|
|
|
|
|
A. Woods, D. Azzout-Marniche, M. Foretz, S. C. Stein, P. Lemarchand, P. Ferré, F. Foufelle, and D. Carling Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase Mol. Cell. Biol., September 15, 2000; 20(18): 6704 - 6711. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ashrafi, S. S. Lin, J. K. Manchester, and J. I. Gordon Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae Genes & Dev., August 1, 2000; 14(15): 1872 - 1885. [Abstract] [Full Text]
|
|
|
|
|
|
R. Schneiter, C. E. Guerra, M. Lampl, V. Tatzer, G. Zellnig, H. L. Klein, and S. D. Kohlwein A Novel Cold-Sensitive Allele of the Rate-Limiting Enzyme of Fatty Acid Synthesis, Acetyl Coenzyme A Carboxylase, Affects the Morphology of the Yeast Vacuole through Acylation of Vac8p Mol. Cell. Biol., May 1, 2000; 20(9): 2984 - 2995. [Abstract] [Full Text]
|
|
|
|
|
|
C. Sugden, P. G. Donaghy, N. G. Halford, and D. G. Hardie Two SNF1-Related Protein Kinases from Spinach Leaf Phosphorylate and Inactivate 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, Nitrate Reductase, and Sucrose Phosphate Synthase in Vitro Plant Physiology, May 1, 1999; 120(1): 257 - 274. [Abstract] [Full Text]
|
|
|
|
|
|
N. B. Ruderman, A. K. Saha, D. Vavvas, and L. A. Witters Malonyl-CoA, fuel sensing, and insulin resistance Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E1 - E18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Crute, K. Seefeld, J. Gamble, B. E. Kemp, and L. A. Witters Functional Domains of the alpha 1 Catalytic Subunit of the AMP-activated Protein Kinase J. Biol. Chem., December 25, 1998; 273(52): 35347 - 35354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Treitel, S. Kuchin, and M. Carlson Snf1 Protein Kinase Regulates Phosphorylation of the Mig1 Repressor in Saccharomyces cerevisiae Mol. Cell. Biol., November 1, 1998; 18(11): 6273 - 6280. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. M. Gancedo Yeast Carbon Catabolite Repression Microbiol. Mol. Biol. Rev., June 1, 1998; 62(2): 334 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ludin, R. Jiang, and M. Carlson Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae PNAS, May 26, 1998; 95(11): 6245 - 6250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thornton, M. A. Snowden, and D. Carling Identification of a Novel AMP-activated Protein Kinase beta Subunit Isoform That Is Highly Expressed in Skeletal Muscle J. Biol. Chem., May 15, 1998; 273(20): 12443 - 12450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. I. Mitchelhill, B. J. Michell, C. M. House, D. Stapleton, J. Dyck, J. Gamble, C. Ullrich, L. A. Witters, and B. E. Kemp Posttranslational Modifications of the 5'-AMP-activated Protein Kinase beta 1 Subunit J. Biol. Chem., September 26, 1997; 272(39): 24475 - 24479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Jiang and M Carlson Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes & Dev., December 15, 1996; 10(24): 3105 - 3115. [Abstract] [PDF]
|
|
|
|
|
|
B. J. Michell, D. Stapleton, K. I. Mitchelhill, C. M. House, F. Katsis, L. A. Witters, and B. E. Kemp Isoform-specific Purification and Substrate Specificity of the 5'-AMP-activated Protein Kinase J. Biol. Chem., November 8, 1996; 271(45): 28445 - 28450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Hawley, M. Davison, A. Woods, S. P. Davies, R. K. Beri, D. Carling, and D. G. Hardie Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase J. Biol. Chem., November 1, 1996; 271(44): 27879 - 27887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R.B. Dyck, G. Gao, J. Widmer, D. Stapleton, C. S. Fernandez, B. E. Kemp, and L. A. Witters Regulation of 5'-AMP-activated Protein Kinase Activity by the Noncatalytic beta and gamma Subunits J. Biol. Chem., July 26, 1996; 271(30): 17798 - 17803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Su, E. Erikson, and J. L. Maller Cloning and Characterization of a Novel Serine/Threonine Protein Kinase Expressed in Early Xenopus Embryos J. Biol. Chem., June 14, 1996; 271(24): 14430 - 14437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Edelman, K. I. Mitchelhill, M. A. Selbert, K. A. Anderson, S. S. Hook, D. Stapleton, E. G. Goldstein, A. R. Means, and B. E. Kemp Multiple Ca[IMAGE]-Calmodulin-dependent Protein Kinase Kinases from Rat Brain J. Biol. Chem., May 3, 1996; 271(18): 10806 - 10810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Woods, P. C. F. Cheung, F. C. Smith, M. D. Davison, J. Scott, R. K. Beri, and D. Carling Characterization of AMP-activated Protein Kinase beta and [IMAGE] Subunits J. Biol. Chem., April 26, 1996; 271(17): 10282 - 10290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gao, C. S. Fernandez, D. Stapleton, A. S. Auster, J. Widmer, J. R. B. Dyck, B. E. Kemp, and L. A. Witters Non-catalytic beta- and [IMAGE]-Subunit Isoforms of the 5`-AMP-activated Protein Kinase J. Biol. Chem., April 12, 1996; 271(15): 8675 - 8681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Stapleton, K. I. Mitchelhill, G. Gao, J. Widmer, B. J. Michell, T. Teh, C. M. House, C. S. Fernandez, T. Cox, L. A. Witters, et al. Mammalian AMP-activated Protein Kinase Subfamily J. Biol. Chem., January 12, 1996; 271(2): 611 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. McCartney and M. C. Schmidt Regulation of Snf1 Kinase. ACTIVATION REQUIRES PHOSPHORYLATION OF THREONINE 210 BY AN UPSTREAM KINASE AS WELL AS A DISTINCT STEP MEDIATED BY THE Snf4 SUBUNIT J. Biol. Chem., September 21, 2001; 276(39): 36460 - 36466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Halfter, M. Ishitani, and J.-K. Zhu The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3 PNAS, March 28, 2000; 97(7): 3735 - 3740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, M. Ishitani, U. Halfter, C.-S. Kim, and J.-K. Zhu The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance PNAS, March 28, 2000; 97(7): 3730 - 3734. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
