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J. Biol. Chem., Vol. 269, Issue 4, 2491-2500, 01, 1994
P Loyer, D Glaise, S Cariou, G Baffet, L Meijer and C Guguen-Guillouzo
In normal adult liver, hepatocytes are arrested in G0, and they rapidly
respond to a mass loss by a definite number of divisions. Thus, taking
advantage of the in vivo regenerative capacity of the liver following
partial hepatectomy, we have analyzed both expression and activation of
p34cdc2 (= cdk1) and p33cdk2 through the cell cycle, particularly during
the long lasting G1 phase and in the G1/S transition. While p33cdk2 is
constantly expressed during the cell cycle, p34cdc2 is completely absent in
resting hepatocytes and remains unexpressed for up to 20 h after partial
hepatectomy, a time period corresponding to the G1 phase and G1/S
transition, and then accumulates in the S, G2, and M phases. No histone H1
kinase activity is detected during the G1 phase, while two peaks of p34cdc2
kinase activity are observed during the S and M phases and only one peak of
p33cdk2 kinase activity in the S phase. p34cdc2 forms complexes with both
cyclins A and B while p33cdk2 is associated with cyclin A only.
Surprisingly, cyclins E and D1 are present in resting liver and with modest
variation throughout the cell cycle. Taken together, our data provide
evidence that the pattern of G1- associated proteins in hepatocytes during
liver regeneration is distinct from that described in other cell types.
Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration
Institut National de la Sante et de la Recherche Medicale U49, Unite de Recherches Hepatologiques, Hopital Pontchaillou, Rennes, France.
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