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J. Biol. Chem., Vol. 269, Issue 4, 2607-2612, Jan, 1994
B Matzenbach, Y Maulet, L Sefton, B Courtier, P Avner, JL Guenet and H Betz
The inhibitory glycine receptor is a ligand-gated ion channel protein that
occurs in different developmentally regulated isoforms in the mammalian
central nervous system. Here, we have analyzed genomic clones covering the
coding regions of the murine glycine receptor alpha 1 and alpha 2 subunit
genes. Both genes contain eight intronic regions with precisely conserved
boundaries. The same structure was also found for seven exons of a third
homologous gene, alpha 4, identified during screening. The predicted alpha
4 polypeptide displays very high homology to the alpha 2 subunit. Like the
alpha 2 gene, the alpha 4 gene maps to the mouse X chromosome. Our data
indicate that the genomic organization of glycine receptor alpha subunit
genes is conserved during evolution.
Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant
Department of Neurochemistry, Max-Planck-Institute for Brain Research, Frankfurt, Germany.
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