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J. Biol. Chem., Vol. 269, Issue 40, 24527-24530, 10, 1994
T Lemberger, B Staels, R Saladin, B Desvergne, J Auwerx and W Wahli
This study demonstrates that the expression of the peroxisome
proliferator-activated receptor alpha (PPAR alpha) is regulated by
glucocorticoid hormones in hepatocytes. Hydrocortisone, dexamethasone, and
triamcinolone stimulated PPAR alpha mRNA synthesis in a dose- dependent
manner in primary rat hepatocyte cultures. This glucocorticoid stimulation
was inhibited by RU 486, a specific glucocorticoid antagonist. Moreover, in
contrast to glucocorticoid hormones, the mineralocorticoid aldosterone had
only a weak effect, suggesting that the hormonal stimulation of PPAR alpha
was mediated by the glucocorticoid receptor. The induction was not
prevented by cycloheximide treatment of the hepatocytes, indicating that it
was mediated by preexisting glucocorticoid receptor. Finally, the RNA
synthesis inhibitor actinomycin D abolished the stimulatory effect of
dexamethasone, and nuclear run-on analysis showed an increase of PPAR alpha
transcripts after hormonal induction. Thus, the PPAR alpha gene is an early
response gene of glucocorticoids that control its expression at the
transcriptional level.
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids
Institut de Biologie Animale, Batiment de Biologie, Universite de Lausanne, Switzerland.
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T. Gotoh, S. Chowdhury, M. Takiguchi, and M. Mori The Glucocorticoid-responsive Gene Cascade. ACTIVATION OF THE RAT ARGINASE GENE THROUGH INDUCTION OF C/EBPbeta J. Biol. Chem., February 7, 1997; 272(6): 3694 - 3698. [Abstract] [Full Text] [PDF]
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B. J. Ledwith, C. J. Pauley, L. K. Wagner, C. L. Rokos, D. W. Alberts, and S. Manam Induction of Cyclooxygenase-2 Expression by Peroxisome Proliferators and Non-tetradecanoylphorbol 12,13-Myristate-type Tumor Promoters in Immortalized Mouse Liver Cells J. Biol. Chem., February 7, 1997; 272(6): 3707 - 3714. [Abstract] [Full Text] [PDF]
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T. Lemberger, Rég. Saladin, M. Vázquez, F.ço. Assimacopoulos, B. Staels, Béa. Desvergne, W. Wahli, and J. Auwerx Expression of the Peroxisome Proliferator-activated Receptor alpha Gene Is Stimulated by Stress and Follows a Diurnal Rhythm J. Biol. Chem., January 19, 1996; 271(3): 1764 - 1769. [Abstract] [Full Text] [PDF]
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