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J. Biol. Chem., Vol. 269, Issue 40, 24553-24556, Oct, 1994

Potential of azidothymidine to activate the HIV-1 promoter

S Kurata
Department of Biochemical Genetics, Tokyo Medical and Dental University, Japan.

Azidothymidine (AZT) has been used for treatment of acquired immunodeficiency syndrome (AIDS), but a recent concord trial showed that it is ineffective for suppressing the development of AIDS. In this study, the effects of AZT on three cell lines transformed by pCD12 plasmid (human immunodeficiency virus-1 (HIV-1) promoter- chloramphenicol acetyltransferase) were examined. Results showed that AZT has the potential to activate the HIV-1 promoter.
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This article has been cited by other articles:

				S.-i. Kurata and S. Kurata Sensitization of the HIV-1-LTR upon Long Term Low Dose Oxidative Stress J. Biol. Chem., September 6, 1996; 271(36): 21798 - 21802. [Abstract] [Full Text] [PDF]