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J. Biol. Chem., Vol. 269, Issue 40, 24627-24636, Oct, 1994
CY Liu, G Zhu, R Converse, CW Kao, H Nakamura, SC Tseng, MM Mui, J Seyer, MJ Justice and ME Stech
Keratins are a group of water-insoluble proteins constituting paired acidic
and basic keratin molecules that form 10-nm intermediate filaments in
epithelial cells. Expression of the K3/K12 keratin pair characterizes the
cornea-type differentiation. However, the mechanism that regulates this
cornea-specific K12 expression remains unknown. To provide a better
understanding of the cornea-specific expression, we have cloned the K12
cDNA (Liu, C.-Y., Zhu, G., Westerhausen-Larson, A., Converse, R., Kao, C.
W.-C., Sun, T.-T., and Kao, W. W.-Y. (1993) Curr. Eye Res. 12, 963-974). In
present studies, the murine K12 keratin gene (Krt1.12) was isolated and
characterized. The murine Krt1.12 gene spans 6,567 base pairs of genomic
DNA, and the mRNA encoding K12 keratin is distributed into eight exons.
Chromosome mapping reveals that murine Krt1.12 is located within the Krt1
complex of mouse chromosome 11. In addition to the production of authentic
K12 mRNA, the Krt1.12 gene gives rise to several alternate poly(A)+ RNAs by
the use of alternative splicing in intron 2, an alternative promoter in
intron 1, and/or both. Sequence analysis indicates that the transcripts
derived from alternative splicing and/or the alternative promoter do not
have a long open reading frame for keratin or keratin-like molecules. It is
not known whether these alternate K12 poly(A)+ RNAs have any biological
functions, e.g. regulation of K12 gene expression.
Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12
Department of Ophthalmology, University of Cincinnati, Ohio 45267-0527.
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