| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 42, 26006-26010, 10, 1994
T Kamata and Y Takada
Integrin alpha 2 beta 1 is a major divalent cation-dependent receptor for
collagen. Here, we show that the recombinant inserted/interactive domain (I
domain) of alpha 2 specifically interacts with collagen, indicating the I
domain contains all the components necessary for collagen binding. Evidence
was obtained that divalent cations are not required for collagen binding to
the I domain fragment, indicating that divalent cations are not involved in
the actual binding to collagen but probably in the regulation of the
binding. We identified Thr-221 within the previously identified putative
ligand binding region as a residue critical for collagen binding to both
alpha 2 beta 1 and the I domain fragment. Thr-221 may be involved in the
actual collagen binding and recognition.
Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner
Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  L. J. Lambert, A. A. Bobkov, J. W. Smith, and F. M. Marassi Competitive Interactions of Collagen and a Jararhagin-derived Disintegrin Peptide with the Integrin {alpha}2-I Domain J. Biol. Chem., June 13, 2008; 283(24): 16665 - 16672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Staelens, M. A. Hadders, S. Vauterin, C. Platteau, M. De Maeyer, K. Vanhoorelbeke, E. G. Huizinga, and H. Deckmyn Paratope Determination of the Antithrombotic Antibody 82D6A3 Based on the Crystal Structure of Its Complex with the von Willebrand Factor A3-Domain J. Biol. Chem., January 27, 2006; 281(4): 2225 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Van de Walle, K. Vanhoorelbeke, Z. Majer, E. Illyes, J. Baert, I. Pareyn, and H. Deckmyn Two Functional Active Conformations of the Integrin {alpha}2{beta}1, Depending on Activation Condition and Cell Type J. Biol. Chem., November 4, 2005; 280(44): 36873 - 36882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jokinen, E. Dadu, P. Nykvist, J. Kapyla, D. J. White, J. Ivaska, P. Vehvilainen, H. Reunanen, H. Larjava, L. Hakkinen, et al. Integrin-mediated Cell Adhesion to Type I Collagen Fibrils J. Biol. Chem., July 23, 2004; 279(30): 31956 - 31963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schoolmeester, K. Vanhoorelbeke, S. Katsutani, H. Depraetere, H. B. Feys, J. M. W. Heemskerk, M. F. Hoylaerts, and H. Deckmyn Monoclonal antibody IAC-1 is specific for activated {alpha}2{beta}1 and binds to amino acids 199 to 201 of the integrin {alpha}2 I-domain Blood, July 15, 2004; 104(2): 390 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Yang, C.-S. Chien, C.-C. Yao, L.-D. Hsiao, Y.-C. Huang, and C. B. Wu Mechanical Strain Induces Collagenase-3 (MMP-13) Expression in MC3T3-E1 Osteoblastic Cells J. Biol. Chem., May 21, 2004; 279(21): 22158 - 22165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Bradley, J. Mogridge, G. Jonah, A. Rainey, S. Batty, and J. A. T. Young Binding of Anthrax Toxin to Its Receptor Is Similar to {alpha} Integrin-Ligand Interactions J. Biol. Chem., December 5, 2003; 278(49): 49342 - 49347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Vanhoorelbeke, H. Depraetere, R. A. P. Romijn, E. G. Huizinga, M. De Maeyer, and H. Deckmyn A Consensus Tetrapeptide Selected by Phage Display Adopts the Conformation of a Dominant Discontinuous Epitope of a Monoclonal Anti-VWF Antibody That Inhibits the von Willebrand Factor-Collagen Interaction J. Biol. Chem., September 26, 2003; 278(39): 37815 - 37821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Graham, P. Halasz, Y. Tan, M. J. Hewish, Y. Takada, E. R. Mackow, M. K. Robinson, and B. S. Coulson Integrin-Using Rotaviruses Bind {alpha}2{beta}1 Integrin {alpha}2 I Domain via VP4 DGE Sequence and Recognize {alpha}X{beta}2 and {alpha}V{beta}3 by Using VP7 during Cell Entry J. Virol., September 15, 2003; 77(18): 9969 - 9978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lahav, E. M. Wijnen, O. Hess, S. W. Hamaia, D. Griffiths, M. Makris, C. G. Knight, D. W. Essex, and R. W. Farndale Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin {alpha}2{beta}1 Blood, September 15, 2003; 102(6): 2085 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Londrigan, K. L. Graham, Y. Takada, P. Halasz, and B. S. Coulson Monkey Rotavirus Binding to {alpha}2{beta}1 Integrin Requires the {alpha}2 I Domain and Is Facilitated by the Homologous {beta}1 Subunit J. Virol., September 1, 2003; 77(17): 9486 - 9501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ball, J. Bella, C. Kielty, and A. Shuttleworth Structural Basis of Type VI Collagen Dimer Formation J. Biol. Chem., April 18, 2003; 278(17): 15326 - 15332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ekholm, K. D. Hankenson, H. Uusitalo, A. Hiltunen, H. Gardner, J. Heino, and R. Penttinen Diminished Callus Size and Cartilage Synthesis in {alpha}1{beta}1 Integrin-Deficient Mice during Bone Fracture Healing Am. J. Pathol., May 1, 2002; 160(5): 1779 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Holtkotter, B. Nieswandt, N. Smyth, W. Muller, M. Hafner, V. Schulte, T. Krieg, and B. Eckes Integrin alpha 2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen J. Biol. Chem., March 22, 2002; 277(13): 10789 - 10794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tulla, O. T. Pentikainen, T. Viitasalo, J. Kapyla, U. Impola, P. Nykvist, L. Nissinen, M. S. Johnson, and J. Heino Selective Binding of Collagen Subtypes by Integrin alpha 1I, alpha 2I, and alpha 10I Domains J. Biol. Chem., December 14, 2001; 276(51): 48206 - 48212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nykvist, K. Tasanen, T. Viitasalo, J. Kapyla, J. Jokinen, L. Bruckner-Tuderman, and J. Heino The Cell Adhesion Domain of Type XVII Collagen Promotes Integrin-mediated Cell Spreading by a Novel Mechanism J. Biol. Chem., October 12, 2001; 276(42): 38673 - 38679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nykvist, H. Tu, J. Ivaska, J. Kapyla, T. Pihlajaniemi, and J. Heino Distinct Recognition of Collagen Subtypes by alpha 1beta 1 and alpha 2beta 1 Integrins. alpha 1beta 1 MEDIATES CELL ADHESION TO TYPE XIII COLLAGEN J. Biol. Chem., March 10, 2000; 275(11): 8255 - 8261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Smith, D. Estavillo, J. Emsley, L. A. Bankston, R. C. Liddington, and M. A. Cruz Mapping the Collagen-binding Site in the I Domain of the Glycoprotein Ia/IIa (Integrin alpha 2beta 1) J. Biol. Chem., February 11, 2000; 275(6): 4205 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kapyla, J. Ivaska, R. Riikonen, P. Nykvist, O. Pentikainen, M. Johnson, and J. Heino Integrin alpha 2I Domain Recognizes Type I and Type IV Collagens by Different Mechanisms J. Biol. Chem., February 4, 2000; 275(5): 3348 - 3354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Knight, L. F. Morton, A. R. Peachey, D. S. Tuckwell, R. W. Farndale, and M. J. Barnes The Collagen-binding A-domains of Integrins alpha 1beta 1 and alpha 2beta 1 Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens J. Biol. Chem., January 7, 2000; 275(1): 35 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Estavillo, A. Ritchie, T. G. Diacovo, and M. A. Cruz Functional Analysis of a Recombinant Glycoprotein Ia/IIa (Integrin alpha 2beta 1) I Domain That Inhibits Platelet Adhesion to Collagen and Endothelial Matrix under Flow Conditions J. Biol. Chem., December 10, 1999; 274(50): 35921 - 35926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kamata, R. C. Liddington, and Y. Takada Interaction between Collagen and the alpha 2 I-domain of Integrin alpha 2beta 1. CRITICAL ROLE OF CONSERVED RESIDUES IN THE METAL ION-DEPENDENT ADHESION SITE (MIDAS) REGION J. Biol. Chem., November 5, 1999; 274(45): 32108 - 32111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pentikainen, A.-M. Hoffren, J. Ivaska, J. Kapyla, T. Nyronen, J. Heino, and M. S. Johnson "RKKH" Peptides from the Snake Venom Metalloproteinase of Bothrops jararaca Bind Near the Metal Ion-dependent Adhesion Site of the Human Integrin alpha 2 I-domain J. Biol. Chem., October 29, 1999; 274(44): 31493 - 31505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ivaska, J. Kapyla, O. Pentikainen, A.-M. Hoffren, J. Hermonen, P. Huttunen, M. S. Johnson, and J. Heino A Peptide Inhibiting the Collagen Binding Function of Integrin alpha 2I Domain J. Biol. Chem., February 5, 1999; 274(6): 3513 - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ravanti, J. Heino, C. Lopez-Otin, and V.-M. Kahari Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase J. Biol. Chem., January 22, 1999; 274(4): 2446 - 2455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Li, P. Rieu, D. L. Griffith, D. Scott, and M. Amin Arnaout Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures J. Cell Biol., December 14, 1998; 143(6): 1523 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Depraetere, A. Viaene, S. Deroo, S. Vauterin, and H. Deckmyn Identification of Peptides, Selected by Phage Display Technology, That Inhibit von Willebrand Factor Binding to Collagen Blood, December 1, 1998; 92(11): 4207 - 4211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Edwards, K. L. Fisher, L. G. Presta, and S. C. Bodary Mapping the Intercellular Adhesion Molecule-1 and -2 Binding Site on the Inserted Domain of Leukocyte Function-associated Antigen-1 J. Biol. Chem., October 30, 1998; 273(44): 28937 - 28944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McDowall, B. Leitinger, P. Stanley, P. A. Bates, A. M. Randi, and N. Hogg The I Domain of Integrin Leukocyte Function-associated Antigen-1 Is Involved in a Conformational Change Leading to High Affinity Binding to Ligand Intercellular Adhesion Molecule 1 (ICAM-1) J. Biol. Chem., October 16, 1998; 273(42): 27396 - 27403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Griggs, C. M. Schmidt, and C. P. Carron Characteristics of Cation Binding to the I Domains of LFA-1 and MAC-1. THE LFA-1 I DOMAIN CONTAINS A Ca2+-BINDING SITE J. Biol. Chem., August 21, 1998; 273(34): 22113 - 22119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Camper, U. Hellman, and E. Lundgren-Akerlund Isolation, Cloning, and Sequence Analysis of the Integrin Subunit alpha 10, a beta 1-associated Collagen Binding Integrin Expressed on Chondrocytes J. Biol. Chem., August 7, 1998; 273(32): 20383 - 20389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Newham, S. E. Craig, K. Clark, A. P. Mould, and M. J. Humphries Analysis of Ligand-Induced and Ligand-Attenuated Epitopes on the Leukocyte Integrin {alpha}4{beta}1: VCAM-1, Mucosal Addressin Cell Adhesion Molecule-1, and Fibronectin Induce Distinct Conformational Changes J. Immunol., May 1, 1998; 160(9): 4508 - 4517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Stanley and N. Hogg The I Domain of Integrin LFA-1 Interacts with ICAM-1 Domain 1 at Residue Glu-34 but Not Gln-73 J. Biol. Chem., February 6, 1998; 273(6): 3358 - 3362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Messent, D. Tuckwell, V Knauper, M. Humphries, G Murphy, and J Gavrilovic Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion J. Cell Sci., January 4, 1998; 111(8): 1127 - 1135. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Pujades, R. Alon, R. L. Yauch, A. Masumoto, L. C. Burkly, C. Chen, T. A. Springer, R. R. Lobb, and M. E. Hemler Defining Extracellular Integrin alpha -Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding Mol. Biol. Cell, December 1, 1997; 8(12): 2647 - 2657. [Abstract] [Full Text]
|
|
|
|
|
|
J. Emsley, S. L. King, J. M. Bergelson, and R. C. Liddington Crystal Structure of the I Domain from Integrin alpha 2beta 1 J. Biol. Chem., November 7, 1997; 272(45): 28512 - 28517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. King, T. Kamata, J. A. Cunningham, J. Emsley, R. C. Liddington, Y. Takada, and J. M. Bergelson Echovirus 1 Interaction with the Human Very Late Antigen-2 (Integrin alpha 2beta 1) I Domain. IDENTIFICATION OF TWO INDEPENDENT VIRUS CONTACT SITES DISTINCT FROM THE METAL ION-DEPENDENT ADHESION SITE J. Biol. Chem., November 7, 1997; 272(45): 28518 - 28522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bienkowska, M. Cruz, A. Atiemo, R. Handin, and R. Liddington The von Willebrand Factor A3 Domain Does Not Contain a Metal Ion-dependent Adhesion Site Motif J. Biol. Chem., October 3, 1997; 272(40): 25162 - 25167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Calderwood, D. S. Tuckwell, J. Eble, K. Kuhn, and M. J. Humphries The Integrin alpha 1 A-domain Is a Ligand Binding Site for Collagens and Laminin J. Biol. Chem., May 9, 1997; 272(19): 12311 - 12317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Huang and T. A. Springer Folding of the beta -propeller domain of the integrin alpha L subunit is independent of the I domain and dependent on the beta 2 subunit PNAS, April 1, 1997; 94(7): 3162 - 3167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Dickeson, J. J. Walsh, and S. A. Santoro Contributions of the I and EF Hand Domains to the Divalent Cation-dependent Collagen Binding Activity of the alpha 2beta 1 Integrin J. Biol. Chem., March 21, 1997; 272(12): 7661 - 7668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shih, D Boettiger, and C. Buck Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit J. Cell Sci., January 10, 1997; 110(20): 2619 - 2628. [Abstract] [PDF]
|
|
|
|
|
|
T. G. Goodman and M. L. Bajt Identifying the Putative Metal Ion-dependent Adhesion Site in the beta 2 (CD18) Subunit Required for alpha Lbeta 2 and alpha Mbeta 2 Ligand Interactions J. Biol. Chem., September 27, 1996; 271(39): 23729 - 23736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Tozer, R. C. Liddington, M. J. Sutcliffe, A. H. Smeeton, and J. C. Loftus Ligand Binding to Integrin alpha IIbbeta 3 Is Dependent on a MIDAS-like Domain in the beta 3 Subunit J. Biol. Chem., September 6, 1996; 271(36): 21978 - 21984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Puzon-McLaughlin and Y. Takada Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin beta 1 Subunit J. Biol. Chem., August 23, 1996; 271(34): 20438 - 20443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kamata, A. Irie, M. Tokuhira, and Y. Takada Critical Residues of Integrin alpha IIb Subunit for Binding of alpha IIbbeta 3 (Glycoprotein IIb-IIIa) to Fibrinogen and Ligand-mimetic Antibodies (PAC-1, OP-G2, and LJ-CP3) J. Biol. Chem., August 2, 1996; 271(31): 18610 - 18615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang and E. F. Plow Overlapping, but Not Identical, Sites Are Involved in the Recognition of C3bi, Neutrophil Inhibitory Factor, and Adhesive Ligands by the alpha Mbeta 2 Integrin J. Biol. Chem., July 26, 1996; 271(30): 18211 - 18216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Binnerts, Y. van Kooyk, C. P. Edwards, M. Champe, L. Presta, S. C. Bodary, C. G. Figdor, and P. W. Berman Antibodies That Selectively Inhibit Leukocyte Function-associated Antigen 1 Binding to Intercellular Adhesion Molecule-3 Recognize a Unique Epitope within the CD11a I Domain J. Biol. Chem., April 26, 1996; 271(17): 9962 - 9968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mould Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes J. Cell Sci., January 11, 1996; 109(11): 2613 - 2618. [PDF]
|
|
|
|
|
|
F Ruggiero, J Comte, C Cabanas, and R Garrone Structural requirements for alpha 1 beta 1 and alpha 2 beta 1 integrin mediated cell adhesion to collagen V J. Cell Sci., January 7, 1996; 109(7): 1865 - 1874. [Abstract] [PDF]
|
|
|
|
|
|
S. L. McGuire and M. L. Bajt Distinct Ligand Binding Sites in the I Domain of Integrin alpha(M)beta(2) That Differentially Affect a Divalent Cation-dependent Conformation J. Biol. Chem., October 27, 1995; 270(43): 25866 - 25871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Haudenschild, M. M. Tondravi, U. Hofer, Q. Chen, and P. F. Goetinck The Role of Coiled-coil alpha-Helices and Disulfide Bonds in the Assembly and Stabilization of Cartilage Matrix Protein Subunits J. Biol. Chem., September 29, 1995; 270(39): 23150 - 23154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang and T. A. Springer A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1) J. Biol. Chem., August 11, 1995; 270(32): 19008 - 19016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma, P. J. Conrad, D. L. Webb, and M.-L. Blue Aspartate 698 within a Novel Cation Binding Motif in alpha(4) Integrin Is Required for Cell Adhesion J. Biol. Chem., August 4, 1995; 270(31): 18401 - 18407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kamata, R. Wright, and Y. Takada Critical Threonine and Aspartic Acid Residues within the I Domains of [IMAGE]2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi J. Biol. Chem., May 26, 1995; 270(21): 12531 - 12535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Edwards, M. Champe, T. Gonzalez, M. E. Wessinger, S. A. Spencer, L. G. Presta, P. W. Berman, and S. C. Bodary Identification of Amino Acids in the CD11a I-domain Important for Binding of the Leukocyte Function-associated Antigen-1 (LFA-1) to Intercellular Adhesion Molecule-1 (ICAM-1) J. Biol. Chem., May 26, 1995; 270(21): 12635 - 12640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Xiong, R. Li, M. Essafi, T. Stehle, and M. A. Arnaout An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain J. Biol. Chem., December 1, 2000; 275(49): 38762 - 38767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
