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J. Biol. Chem., Vol. 269, Issue 44, 27163-27166, 11, 1994
JQ Davis and V Bennett
Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell
adhesion molecules with conserved cytoplasmic domains that are believed to
play important roles in development of the nervous system. This report
presents biochemical evidence that the cytoplasmic domains of these
molecules associate directly with ankyrins, a family of spectrin-binding
proteins located on the cytoplasmic surface of specialized plasma membrane
domains. Rat neurofascin and NrCAM together comprise over 0.5% of the
membrane protein in adult brain tissue. Linkage of these ankyrin-binding
cell adhesion molecules to spectrin- based structures may provide a major
class of membrane-cytoskeletal connections in adult brain as well as
earlier stages of development.
Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.
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X. Zhang, J. Q. Davis, S. Carpenter, and V. Bennett Structural Requirements for Association of Neurofascin with Ankyrin J. Biol. Chem., November 13, 1998; 273(46): 30785 - 30794. [Abstract] [Full Text] [PDF]
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X. Zhang and V. Bennett Restriction of 480/270-kD Ankyrin G to Axon Proximal Segments Requires Multiple Ankyrin G-specific Domains J. Cell Biol., September 21, 1998; 142(6): 1571 - 1581. [Abstract] [Full Text] [PDF]
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M. Hortsch, D. Homer, J. D. Malhotra, S. Chang, J. Frankel, G. Jefford, and R. R. Dubreuil Structural Requirements for Outside-In and Inside-Out Signaling by Drosophila Neuroglian, a Member of the L1 Family of Cell Adhesion Molecules J. Cell Biol., July 13, 1998; 142(1): 251 - 261. [Abstract] [Full Text] [PDF]
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D. M. Suter, L. D. Errante, V. Belotserkovsky, and P. Forscher The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate-Cytoskeletal Coupling J. Cell Biol., April 6, 1998; 141(1): 227 - 240. [Abstract] [Full Text] [PDF]
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U. Treubert and T. Brummendorf Functional Cooperation of beta 1-Integrins and Members of the Ig Superfamily in Neurite Outgrowth Induction J. Neurosci., March 1, 1998; 18(5): 1795 - 1805. [Abstract] [Full Text] [PDF]
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E Kordeli, M. Ludosky, C Deprette, T Frappier, and J Cartaud AnkyrinG is associated with the postsynaptic membrane and the sarcoplasmic reticulum in the skeletal muscle fiber J. Cell Sci., January 8, 1998; 111(15): 2197 - 2207. [Abstract] [PDF]
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B. Hassel, F. G. Rathjen, and H. Volkmer Organization of the Neurofascin Gene and Analysis of Developmentally Regulated Alternative Splicing J. Biol. Chem., November 7, 1997; 272(45): 28742 - 28749. [Abstract] [Full Text] [PDF]
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