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J. Biol. Chem., Vol. 269, Issue 44, 27167-27170, Nov, 1994

Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells

O Blondel, GI Bell, M Moody, RJ Miller and SJ Gibbons
Howard Hughes Medical Institute, University of Chicago, Illinois 60637.

A rapid rise in the cytosolic free Ca2+ concentration due to influx of extracellular Ca2+ or mobilization from intracellular stores is the primary trigger for exocytosis from secretory cells. Our understanding as to the precise role of Ca2+ mobilization has been complicated by the presence of several types of Ca2+ stores in most cells. We now demonstrate that overexpression of the type 3 inositol 1,4,5- trisphosphate (IP3) receptor in insulin-secreting beta TC-3 cells results in the creation of a unique IP3-sensitive Ca2+ pool, restricted to the insulin secretory granules of these cells.
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