HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ishibashi, S. Articles by Herz, J. Search for Related Content PubMed PubMed Citation Articles by Ishibashi, S. Articles by Herz, J. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 269, Issue 45, 27803-27806, 11, 1994

Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit

S Ishibashi, RE Hammer and J Herz
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.

The asialoglycoprotein receptor is an abundant heterooligomeric endocytic receptor that is predominantly expressed on the sinusoidal surface of the hepatocytes. Proposed physiological and pathophysiological functions ascribed to this hepatic lectin (HL) include the removal of desialylated serum glycoproteins and apoptotic cells, clearance of chylomicron remnants, and a role as a homing receptor for lymphatic and metastatic cells. The assembly of two homologous subunits, HL-1 and HL-2, is required to form functional, high affinity receptors on the cell surface. However, the importance of the individual subunits for receptor transport to the cell surface has been controversial. To explore the significance of the minor HL-2 subunit for receptor expression and function in vivo, we have disrupted the HL-2 gene in mice. Homozygous HL-2-deficient animals are superficially normal. However, HL-1 expression in the liver is greatly reduced, indicating that HL-2 may promote HL-1 stability. Although these mice are completely unable to clear asialoorosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in their circulation.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. J. Coombs, M. E. Taylor, and K. Drickamer Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling Glycobiology, August 1, 2006; 16(8): 1C - 7C. [Abstract] [Full Text] [PDF]

				E. I. Park, Y. Mi, C. Unverzagt, H.-J. Gabius, and J. U. Baenziger The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid{alpha}2,6GalNAc PNAS, November 22, 2005; 102(47): 17125 - 17129. [Abstract] [Full Text] [PDF]

				P. J. Coombs, S. A. Graham, K. Drickamer, and M. E. Taylor Selective Binding of the Scavenger Receptor C-type Lectin to Lewisx Trisaccharide and Related Glycan Ligands J. Biol. Chem., June 17, 2005; 280(24): 22993 - 22999. [Abstract] [Full Text] [PDF]

				J. H. N. Yik and P. H. Weigel The Position of Cysteine Relative to the Transmembrane Domain Is Critical for Palmitoylation of H1, the Major Subunit of the Human Asialoglycoprotein Receptor J. Biol. Chem., November 27, 2002; 277(49): 47305 - 47312. [Abstract] [Full Text] [PDF]

				N. J. Mantis, M. C. Cheung, K. R. Chintalacharuvu, J. Rey, B. Corthesy, and M. R. Neutra Selective Adherence of IgA to Murine Peyer's Patch M Cells: Evidence for a Novel IgA Receptor J. Immunol., August 15, 2002; 169(4): 1844 - 1851. [Abstract] [Full Text] [PDF]

				S. J. Lee, S. Evers, D. Roeder, A. F. Parlow, J. Risteli, L. Risteli, Y. C. Lee, T. Feizi, H. Langen, and M. C. Nussenzweig Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis Science, March 8, 2002; 295(5561): 1898 - 1901. [Abstract] [Full Text] [PDF]

				A. Rifai, K. Fadden, S. L. Morrison, and K. R. Chintalacharuvu The N-Glycans Determine the Differential Blood Clearance and Hepatic Uptake of Human Immunoglobulin (Ig)A1 and IgA2 Isotypes J. Exp. Med., June 19, 2000; 191(12): 2171 - 2182. [Abstract] [Full Text] [PDF]

				M. Trommsdorff, J.-P. Borg, B. Margolis, and J. Herz Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein J. Biol. Chem., December 11, 1998; 273(50): 33556 - 33560. [Abstract] [Full Text] [PDF]

				D. Storm, J. Herz, P. Trinder, and M. Loos C1 Inhibitor-C1s Complexes Are Internalized and Degraded by the Low Density Lipoprotein Receptor-related Protein J. Biol. Chem., December 5, 1997; 272(49): 31043 - 31050. [Abstract] [Full Text] [PDF]

				M. D. Bider, J. M. Wahlberg, R. A. Kammerer, and M. Spiess The Oligomerization Domain of the Asialoglycoprotein Receptor Preferentially Forms 2:2 Heterotetramers in Vitro J. Biol. Chem., December 13, 1996; 271(50): 31996 - 32001. [Abstract] [Full Text] [PDF]

				J. R. Braun, T. E. Willnow, S. Ishibashi, G. Ashwell, and J. Herz The Major Subunit of the Asialoglycoprotein Receptor Is Expressed on the Hepatocellular Surface in Mice Lacking the Minor Receptor Subunit J. Biol. Chem., August 30, 1996; 271(35): 21160 - 21166. [Abstract] [Full Text] [PDF]

				R.-i. Tozawa, S. Ishibashi, J.-i. Osuga, K. Yamamoto, H. Yagyu, K. Ohashi, Y. Tamura, N. Yahagi, Y. Iizuka, H. Okazaki, et al. Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit. ITS OBLIGATE REQUIREMENT FOR THE STABLE EXPRESSION OF OLIGOMERIC RECEPTOR J. Biol. Chem., April 13, 2001; 276(16): 12624 - 12628. [Abstract] [Full Text] [PDF]

				P. C. N. Rensen, L. A. J. M. Sliedregt, M. Ferns, E. Kieviet, S. M. W. van Rossenberg, S. H. van Leeuwen, T. J. C. van Berkel, and E. A. L. Biessen Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytes in Vitro and in Vivo J. Biol. Chem., September 28, 2001; 276(40): 37577 - 37584. [Abstract] [Full Text] [PDF]