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J. Biol. Chem., Vol. 269, Issue 48, 30069-30072, Dec, 1994
HM Hu, K O'Rourke, MS Boguski and VM Dixit
CD40 is a member of the tumor necrosis factor receptor family and, like
other members, it appears to possess no intrinsic signaling capacity (e.g.
kinase activity), suggesting that signal transduction is likely mediated by
associating molecules. To identify such molecules, we have utilized the
yeast two-hybrid system to clone cDNAs encoding proteins that bind the CD40
cytoplasmic domain. One such interacting protein, designated CD40-binding
protein, has a N-terminal RING finger motif that is found in a number of
DNA-binding proteins, including the V(D)J recombination activating gene
RAG1. In addition, it contains a prominent central coiled-coil segment that
may allow homo- or hetero- oligomerization. The C terminus possesses
substantial homology to the tumor necrosis factor receptor-associated
factor (TRAF) domain that is found in two proteins (TRAF1 and TRAF2) that
associate with the cytoplasmic domain of the related 75-kDa tumor necrosis
factor receptor. This is the first identification of a molecule that
interacts with CD40 and whose sequence suggests a potential role in
signaling.
A novel RING finger protein interacts with the cytoplasmic domain of CD40
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.
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|
|
|
|
 |
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
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|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 H. WU, Y.C. PARK, H. YE, and L. TONG Structural Studies of Human TRAF2 Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 541 - 550. [Abstract] [PDF]
|
|
|
|
|
|
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 |
|
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