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J. Biol. Chem., Vol. 269, Issue 48, 30073-30076, Dec, 1994
S Benichou, M Bomsel, M Bodeus, H Durand, M Doute, F Letourneur, J Camonis and R Benarous
Nef is a 27-kDa myristylated protein conserved in most human
immunodeficiency virus (HIV)-1, HIV-2, and simian immunodeficiency virus
isolates. Simian immunodeficiency virus Nef is required in macaques for
both high viral load and full pathological effects. Nef down-regulates the
cell surface expression of CD4 by a post- translational mechanism that is
not yet fully elucidated. We have used the yeast two-hybrid system to
identify cellular proteins that interact with Nef. A cDNA was isolated
which encodes a COOH-terminal fragment of human beta-COP, a major coat
component of non-clathrin-coated vesicles. Nef and beta-COP interacted in
vitro and were found to be physically associated in HIV-1-infected cells by
co-immunoprecipitation. These observations suggest that beta-COP might be
one of the cellular mediators of Nef function in HIV-1-infected cells.
Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic
Unite 332, INSERM, Paris, France.
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