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J. Biol. Chem., Vol. 269, Issue 48, 30097-30100, Dec, 1994
JA Larm, F Vaillant, AW Linnane and A Lawen
We have studied aspects of the regulatory interrelationship between the
plasma membrane oxidoreductase (PMOR) system and the mitochondrial
respiratory capacity of human Namalwa cells. Although the role of
mitochondria in the maintenance of cellular redox and energetic states is
well established, the PMOR system in comparison is a poorly characterized
enzyme system whose functions, particularly in relation to cellular
metabolism, have not been clearly elucidated. Therefore we compared the
PMOR and mitochondrial respiratory activities of human Namalwa cells during
the induction by ethidium bromide treatment of rho 0 cells, which lack a
functional mitochondrial respiratory system. The plasma membrane
NADH-ferricyanide reductase activity of the PMOR system was found to
increase in a stepwise manner concomitant with a decline in cellular
mitochondrial respiratory activity. Addition of p-
chloromercuriphenylsulfonic acid to the culture medium, at a concentration
totally inhibiting the plasma membrane NADH-ferricyanide reductase in
vitro, leads to cell death of rho 0 but not of rho + cells. Thus, the
up-regulation of a functional PMOR system is a necessary phenomenon in
maintaining the viability of mammalian rho 0 cells.
Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
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