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J. Biol. Chem., Vol. 269, Issue 49, 30765-30768, 12, 1994
EE Qwarnstrom, CO Ostberg, GL Turk, CA Richardson and K Bomsztyk
The nuclear factor kappa B, NF-kappa B, is activated by numerous
inflammatory mediators, regulating biological responses that in part are
dependent on the extracellular matrix. Analyses of the influence of
cell-matrix interaction on NF-kappa B activation revealed that attachment
to fibronectin caused an increase in NF-kappa B activity corresponding to
3-fold the level in cells plated on bare plastic. This effect was dependent
on the degree of attachment and appeared to involve both the RGD motif of
the cell-binding domain, and the heparin- binding domain of fibronectin.
Fibronectin attachment specifically caused activation of the p50/p65
heterodimeric form of NF-kappa B, resulting in an increase of this complex
to a level similar to that induced by cytokine stimulation. These data show
that cell attachment has a pronounced influence on the level of NF-kappa B
activity, affecting specific dimeric complexes, and suggest this to be a
pathway through which effects depending on cell-matrix interaction can
regulate cell behavior and cytokine responses.
Fibronectin attachment activates the NF-kappa B p50/p65 heterodimer in fibroblasts and smooth muscle cells
Department of Pathology, University of Washington, Seattle 98195.
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