| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 49, 30777-30780, Dec, 1994
KV Kandror, L Yu and PF Pilch
A glycoprotein of M(r) 160,000 (gp160) represents the major protein
component of GLUT4-containing vesicles other than GLUT4 itself. These
vesicles are the tissue-specific secretory-like microsomal structures that
are responsible for insulin-dependent translocation of GLUT4 to the cell
surface in fat and muscle cells. Our previous studies demonstrated that the
expression of gp160 is also limited to fat and muscle tissues, where it is
localized exclusively in GLUT4-containing vesicles, and thus, it represents
a marker protein for insulin- activated glucose transport. We demonstrate
here that gp160 has structural homology to aminopeptidase N and possesses
aminopeptidase activity in vitro. Since aminopeptidase activity has also
been found in a variety of secretory type vesicles from other tissues, it
may be essential for the organization and functioning of secretory
machinery in different cell types.
The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity
Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Shi, G. Huang, and K. V. Kandror Self-assembly of Glut4 Storage Vesicles during Differentiation of 3T3-L1 Adipocytes J. Biol. Chem., October 31, 2008; 283(44): 30311 - 30321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Blot and T. E. McGraw Molecular Mechanisms Controlling GLUT4 Intracellular Retention Mol. Biol. Cell, August 1, 2008; 19(8): 3477 - 3487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. M. Song, R. C. Hresko, and M. Mueckler Identification of Amino Acid Residues within the C Terminus of the Glut4 Glucose Transporter That Are Essential for Insulin-stimulated Redistribution to the Plasma Membrane J. Biol. Chem., May 2, 2008; 283(18): 12571 - 12585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Watson and J. E. Pessin Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors J. Cell Sci., April 15, 2008; 121(8): 1243 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shi and K. V. Kandror The Luminal Vps10p Domain of Sortilin Plays the Predominant Role in Targeting to Insulin-responsive Glut4-containing Vesicles J. Biol. Chem., March 23, 2007; 282(12): 9008 - 9016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Williams, S. W. Hicks, C. E. Machamer, and J. E. Pessin Golgin-160 Is Required for the Golgi Membrane Sorting of the Insulin-responsive Glucose Transporter GLUT4 in Adipocytes Mol. Biol. Cell, December 1, 2006; 17(12): 5346 - 5355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hosaka, C. C. Brooks, E. Presman, S.-K. Kim, Z. Zhang, M. Breen, D. N. Gross, E. Sztul, and P. F. Pilch p115 Interacts with the GLUT4 Vesicle Protein, IRAP, and Plays a Critical Role in Insulin-stimulated GLUT4 Translocation Mol. Biol. Cell, June 1, 2005; 16(6): 2882 - 2890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Diaz-Perales, V. Quesada, L. M. Sanchez, A. P. Ugalde, M. F. Suarez, A. Fueyo, and C. Lopez-Otin Identification of Human Aminopeptidase O, a Novel Metalloprotease with Structural Similarity to Aminopeptidase B and Leukotriene A4 Hydrolase J. Biol. Chem., April 8, 2005; 280(14): 14310 - 14317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Watson, M. Kanzaki, and J. E. Pessin Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes Endocr. Rev., April 1, 2004; 25(2): 177 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kobayashi, S. Nomura, T. Mitsui, T. Ito, N. Kuno, Y. Ohno, K. Kadomatsu, T. Muramatsu, T. Nagasaka, and S. Mizutani Tissue Distribution of Placental Leucine Aminopeptidase/Oxytocinase During Mouse Pregnancy J. Histochem. Cytochem., January 1, 2004; 52(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tojo, I. Kaieda, H. Hattori, N. Katayama, K. Yoshimura, S. Kakimoto, Y. Fujisawa, E. Presman, C. C. Brooks, and P. F. Pilch The Formin Family Protein, Formin Homolog Overexpressed in Spleen, Interacts with the Insulin-Responsive Aminopeptidase and Profilin IIa Mol. Endocrinol., July 1, 2003; 17(7): 1216 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roh, J. Han, A. Tzatsos, and K. V. Kandror Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E322 - E330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schling and T. Schafer Human Adipose Tissue Cells Keep Tight Control on the Angiotensin II Levels in Their Vicinity J. Biol. Chem., December 6, 2002; 277(50): 48066 - 48075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vauquelin, Y. Michotte, I. Smolders, S. Sarre, G. Ebinger, A. Dupont, and P. Vanderheyden Cellular targets for angiotensin II fragments: pharmacological and molecular evidence Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 195 - 204. [Abstract] [PDF]
|
|
|
|
|
|
L. L. Tortorella and P. F. Pilch C2C12 myocytes lack an insulin-responsive vesicular compartment despite dexamethasone-induced GLUT4 expression Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E514 - E524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mora, P. L. Durham, J. R. Smith, A. F. Russo, A. Jeromin, and J. E. Pessin NCS-1 Inhibits Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes through a Phosphatidylinositol 4-Kinase-dependent Pathway J. Biol. Chem., July 19, 2002; 277(30): 27494 - 27500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Katagiri, T. Asano, T. Yamada, T. Aoyama, Y. Fukushima, M. Kikuchi, T. Kodama, and Y. Oka Acyl-Coenzyme A Dehydrogenases Are Localized on GLUT4-Containing Vesicles via Association with Insulin-Regulated Aminopeptidase in a Manner Dependent on Its Dileucine Motif Mol. Endocrinol., May 1, 2002; 16(5): 1049 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito, S. Nomura, M. Okada, Y. Katsumata, A. Iwase, F. Kikkawa, M. Tsujimoto, and S. Mizutani Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene Mol. Hum. Reprod., September 1, 2001; 7(9): 887 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mora, C. Yang, J. W. Ryder, D. Boeglin, and J. E. Pessin The MEF2A and MEF2D Isoforms Are Differentially Regulated in Muscle and Adipose Tissue during States of Insulin Deficiency Endocrinology, May 1, 2001; 142(5): 1999 - 2004. [Abstract] [Full Text]
|
|
|
|
|
|
A. O. Johnson, M. A. Lampson, and T. E. McGraw A Di-Leucine Sequence and a Cluster of Acidic Amino Acids Are Required for Dynamic Retention in the Endosomal Recycling Compartment of Fibroblasts Mol. Biol. Cell, February 1, 2001; 12(2): 367 - 381. [Abstract] [Full Text]
|
|
|
|
|
|
M. Zhou, B.-Z. Lin, S. Coughlin, G. Vallega, and P. F. Pilch UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E622 - E629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhou, G. Vallega, K. V. Kandror, and P. F. Pilch Insulin-mediated translocation of GLUT-4-containing vesicles is preserved in denervated muscles Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1019 - E1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Provoda, M. T. Waring, and K. M. Buckley Evidence for a Primary Endocytic Vesicle Involved in Synaptic Vesicle Biogenesis J. Biol. Chem., March 15, 2000; 275(10): 7004 - 7012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Subtil, M. A Lampson, S. R. Keller, and T. E. McGraw Characterization of the Insulin-regulated Endocytic Recycling Mechanism in 3T3-L1 Adipocytes Using a Novel Reporter Molecule J. Biol. Chem., February 18, 2000; 275(7): 4787 - 4795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Brooks, P. E. Scherer, K. Cleveland, J. L. Whittemore, H. F. Lodish, and B. Cheatham Pantophysin Is a Phosphoprotein Component of Adipocyte Transport Vesicles and Associates with GLUT4-containing Vesicles J. Biol. Chem., January 21, 2000; 275(3): 2029 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Thurmond, M. Kanzaki, A. H. Khan, and J. E. Pessin Munc18c Function Is Required for Insulin-Stimulated Plasma Membrane Fusion of GLUT4 and Insulin-Responsive Amino Peptidase Storage Vesicles Mol. Cell. Biol., January 1, 2000; 20(1): 379 - 388. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Elmendorf, D. J. Boeglin, and J. E. Pessin Temporal Separation of Insulin-stimulated GLUT4/IRAP Vesicle Plasma Membrane Docking and Fusion in 3T3L1 Adipocytes J. Biol. Chem., December 24, 1999; 274(52): 37357 - 37361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. El-Jack, K. V. Kandror, and P. F. Pilch The Formation of an Insulin-responsive Vesicular Cargo Compartment Is an Early Event in 3T3-L1 Adipocyte Differentiation Mol. Biol. Cell, May 1, 1999; 10(5): 1581 - 1594. [Abstract] [Full Text]
|
|
|
|
|
|
D. C. Thurmond, B. P. Ceresa, S. Okada, J. S. Elmendorf, K. Coker, and J. E. Pessin Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes J. Biol. Chem., December 11, 1998; 273(50): 33876 - 33883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Summers, L. A. Garza, H. Zhou, and M. J. Birnbaum Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide Mol. Cell. Biol., September 1, 1998; 18(9): 5457 - 5464. [Abstract] [Full Text]
|
|
|
|
|
|
B. Lin, S. Coughlin, and P. F. Pilch Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E386 - E391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhou, L. Sevilla, G. Vallega, P. Chen, M. Palacin, A. Zorzano, P. F. Pilch, and K. V. Kandror Insulin-dependent protein trafficking in skeletal muscle cells Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E187 - E196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Johnson, A. Subtil, R. Petrush, K. Kobylarz, S. R. Keller, and T. E. McGraw Identification of an Insulin-responsive, Slow Endocytic Recycling Mechanism in Chinese Hamster Ovary Cells J. Biol. Chem., July 10, 1998; 273(28): 17968 - 17977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Morris, S. A. Ross, W. S. Lane, S. K. Moestrup, C. M. Petersen, S. R. Keller, and G. E. Lienhard Sortilin Is the Major 110-kDa Protein in GLUT4 Vesicles from Adipocytes J. Biol. Chem., February 6, 1998; 273(6): 3582 - 3587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-Z. Lin, P. F. Pilch, and K. V. Kandror Sortilin Is a Major Protein Component of Glut4-containing Vesicles J. Biol. Chem., September 26, 1997; 272(39): 24145 - 24147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Waters, M. D'Auria, S. S. Martin, C. Nguyen, L. M. Kozma, and K. L. Luskey The Amino Terminus of Insulin-responsive Aminopeptidase Causes Glut4 Translocation in 3T3-L1 Adipocytes J. Biol. Chem., September 12, 1997; 272(37): 23323 - 23327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Malide, N. K. Dwyer, E. J. Blanchette-Mackie, and S. W. Cushman Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin J. Histochem. Cytochem., August 1, 1997; 45(8): 1083 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Mastick and A. L. Falick Association of N-Ethylmaleimide Sensitive Fusion (NSF) Protein and Soluble NSF Attachment Proteins-{alpha} and -{gamma} with Glucose Transporter-4-Containing Vesicles in Primary Rat Adipocytes Endocrinology, June 1, 1997; 138(6): 2391 - 2397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sumitani, T. Ramlal, R. Somwar, S. R. Keller, and A. Klip Insulin Regulation and Selective Segregation with Glucose Transporter-4 of the Membrane Aminopeptidase vp165 in Rat Skeletal Muscle Cells Endocrinology, March 1, 1997; 138(3): 1029 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Martin, J. Rice, G. Gould, S. Keller, J. Slot, and D. James The glucose transporter GLUT4 and the aminopeptidase vp165 colocalise in tubulo-vesicular elements in adipocytes and cardiomyocytes J. Cell Sci., January 9, 1997; 110(18): 2281 - 2291. [Abstract] [PDF]
|
|
|
|
|
|
K. V. Kandror and P. F. Pilch The Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor Utilizes the Same Membrane Compartments as GLUT4 for Insulin-dependent Trafficking to and from the Rat Adipocyte Cell Surface J. Biol. Chem., September 6, 1996; 271(36): 21703 - 21708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tozzo, B. B. Kahn, P. F. Pilch, and K. V. Kandror Glut4 Is Targeted to Specific Vesicles in Adipocytes of Transgenic Mice Overexpressing Glut4 Selectively in Adipose Tissue J. Biol. Chem., May 3, 1996; 271(18): 10490 - 10494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Ross, H. M. Scott, N. J. Morris, W.-Y. Leung, F. Mao, G. E. Lienhard, and S. R. Keller Characterization of the Insulin-regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes J. Biol. Chem., February 9, 1996; 271(6): 3328 - 3332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Thorens and J Roth Intracellular targeting of GLUT4 in transfected insulinoma cells: evidence for association with constitutively recycling vesicles distinct from synaptophysin and insulin vesicles J. Cell Sci., January 6, 1996; 109(6): 1311 - 1323. [Abstract] [PDF]
|
|
|
|
|
|
L. Coderre, K. V. Kandror, G. Vallega, and P. F. Pilch Identification and Characterization of an Exercise-sensitive Pool of Glucose Transporters in Skeletal Muscle J. Biol. Chem., November 17, 1995; 270(46): 27584 - 27588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Keller, H. M. Scott, C. C. Mastick, R. Aebersold, and G. E. Lienhard Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles J. Biol. Chem., October 6, 1995; 270(40): 23612 - 23618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Kupriyanova and K. V. Kandror Cellugyrin Is a Marker for a Distinct Population of Intracellular Glut4-containing Vesicles J. Biol. Chem., November 10, 2000; 275(46): 36263 - 36268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-W. Chi and H. F. Lodish Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles J. Biol. Chem., December 1, 2000; 275(49): 38437 - 38444. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
