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J. Biol. Chem., Vol. 269, Issue 5, 3129-3131, Feb, 1994

Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones

PA Ferreira and WL Pak
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

The Drosophila norpA gene encodes a phosphatidylinositol-specific phospholipase C (PI-PLC) expressed predominantly in photoreceptors and involved in phototransduction. However, no direct role for a phospholipase C in vertebrate phototransduction has been identified to date. Recently, we reported the isolation and characterization of bovine cDNAs encoding PI-PLC isoforms expressed predominantly in the retina and with higher homology to the NorpA protein than to any other known PI-PLC. Here, we present evidence that the norpA-homologous bovine retinal PI-PLCs, although found in other retinal neurons as well, are found in cones but not in rods. The results suggest that the phototransduction cascade in cones may utilize phospholipase C in addition to phosphodiesterase.
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