| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 269, Issue 7, 4917-4921, 02, 1994
S Mori, L Ronnstrand, L Claesson-Welsh and CH Heldin
The importance of tyrosine residues in ligand-mediated endocytosis of the
platelet-derived growth factor beta-receptor was analyzed using a series of
tyrosine residue-mutated beta-receptors, which together cover all of the
tyrosine residues in the juxtamembrane segment, the kinase insert, and the
carboxyl-terminal tail; also certain of the tyrosine residues within the
first and second parts of the kinase domain were examined. Of all of these
tyrosine residues, only Tyr-579 seemed to be important for internalization,
since mutation of this residue resulted in substantial reduction in the
rate of ligand-induced receptor internalization (approximately 60% of the
wild-type level). Replacement of Tyr-579 by either an aromatic (Phe) or a
nonaromatic (Asp) residue reduced the efficiency of the mutant receptors in
internalization to the same extent, suggesting that the role of Tyr-579 in
the beta- receptor is different from that of the previously described
tyrosine- based internalization motifs, which were first determined for the
low density lipoprotein receptor. Tyr-579 has been found to be an
autophosphorylation site in the beta-receptor. Moreover, the
internalization rate of a kinase negative receptor mutant was not altered
by the additional mutation of Tyr-579. Thus, it is likely that
phosphorylation of Tyr-579 is important for ligand-induced internalization
of the beta-receptor.
A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. De Donatis, G. Comito, F. Buricchi, M. C. Vinci, A. Parenti, A. Caselli, G. Camici, G. Manao, G. Ramponi, and P. Cirri Proliferation Versus Migration in Platelet-derived Growth Factor Signaling: THE KEY ROLE OF ENDOCYTOSIS J. Biol. Chem., July 18, 2008; 283(29): 19948 - 19956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Franco, O. Furstoss, V. Simon, C. Benistant, W. J. Hong, and S. Roche The Adaptor Protein Tom1L1 Is a Negative Regulator of Src Mitogenic Signaling Induced by Growth Factors. Mol. Cell. Biol., March 1, 2006; 26(5): 1932 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wu, D. A. Windmiller, L. Wang, and J. M. Backer YXXM Motifs in the PDGF-{beta} Receptor Serve Dual Roles as Phosphoinositide 3-Kinase Binding Motifs and Tyrosine-based Endocytic Sorting Signals J. Biol. Chem., October 17, 2003; 278(42): 40425 - 40428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Voytyuk, J. Lennartsson, A. Mogi, G. Caruana, S. Courtneidge, L. K. Ashman, and L. Ronnstrand Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit J. Biol. Chem., March 7, 2003; 278(11): 9159 - 9166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hackzell, H. Uramoto, H. Izumi, K. Kohno, and K. Funa p73 Independent of c-Myc Represses Transcription of Platelet-derived Growth Factor beta -Receptor through Interaction with NF-Y J. Biol. Chem., October 11, 2002; 277(42): 39769 - 39776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sorkina, F. Huang, L. Beguinot, and A. Sorkin Effect of Tyrosine Kinase Inhibitors on Clathrin-coated Pit Recruitment and Internalization of Epidermal Growth Factor Receptor J. Biol. Chem., July 19, 2002; 277(30): 27433 - 27441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Chiarugi, P. Cirri, M. L. Taddei, D. Talini, L. Doria, T. Fiaschi, F. Buricchi, E. Giannoni, G. Camici, G. Raugei, et al. New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases J. Cell Sci., May 15, 2002; 115(10): 2219 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Izumi, C Molander, L. Penn, A Ishisaki, K Kohno, and K Funa Mechanism for the transcriptional repression by c-Myc on PDGF (&bgr;)-receptor J. Cell Sci., January 4, 2001; 114(8): 1533 - 1544. [Abstract] [PDF]
|
|
|
|
 |
|
 C.-H. Heldin and B. Westermark Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor Physiol Rev, October 1, 1999; 79(4): 1283 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumoto, K. Yokote, K. Tamura, M. Takemoto, H. Ueno, Y. Saito, and S. Mori Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration J. Biol. Chem., May 14, 1999; 274(20): 13954 - 13960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Strous and R Govers The ubiquitin-proteasome system and endocytosis J. Cell Sci., January 5, 1999; 112(10): 1417 - 1423. [Abstract] [PDF]
|
|
|
|
 |
|
 D. E. Brenneman, J. Hauser, E. Neale, S. Rubinraut, M. Fridkin, A. Davidson, and I. Gozes Activity-Dependent Neurotrophic Factor: Structure-Activity Relationships of Femtomolar-Acting Peptides J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 619 - 627. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Gommerman, R. Rottapel, and S. A. Berger Phosphatidylinositol 3-Kinase and Ca2+ Influx Dependence for Ligand-stimulated Internalization of the c-Kit Receptor J. Biol. Chem., November 28, 1997; 272(48): 30519 - 30525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hamer, C. R. Haft, J.-P. Paccaud, C. Maeder, S. Taylor, and J.-L. Carpentier Dual Role of a Dileucine Motif in Insulin Receptor Endocytosis J. Biol. Chem., August 29, 1997; 272(35): 21685 - 21691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yokote, B. Margolis, C.-H. Heldin, and L. Claesson-Welsh Grb7 is a Downstream Signaling Component of Platelet-derived Growth Factor alpha - and beta -Receptors J. Biol. Chem., November 29, 1996; 271(48): 30942 - 30949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mori, K. Tanaka, S. Omura, and Y. Saito Degradation Process of Ligand-stimulated Platelet-derived Growth Factor beta-Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway J. Biol. Chem., December 8, 1995; 270(49): 29447 - 29452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Joly, A. Kazlauskas, and S. Corvera Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking J. Biol. Chem., June 2, 1995; 270(22): 13225 - 13230. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
