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(Received for publication, November 18, 1994; and in revised form, January
3, 1995) Proliferation of vascular smooth muscle cells (VSMC) is
triggered by two types of growth factors. One activates tyrosine
kinase-type receptors and the other activates G-protein-coupled
receptors. We found that a conditioned medium of rat VSMC contained a
growth-potentiating activity for the latter type of growth factor, and
we purified a 70-kDa growth-potentiating factor (GPF) from the
conditioned medium. Analyses of GPF and its cDNA revealed GPF to be a
Volume 270,
Number 11,
Issue of March 17, 1995 pp. 5702-5705
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
-mobilizing Growth Factors
-carboxyglutamic acid-containing protein encoded by a growth
arrest-specific gene, gas6, which related to protein S. GPF
specifically potentiated cell proliferation mediated by
Ca
-mobilizing receptors. The presence of a specific
binding site suggests that the effect of GPF is mediated by a receptor.
Thus, GPF may be a new type of extracellular factor regulating VSMC
proliferation.
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