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Volume 270,
Number 11,
Issue of March 17, 1995 pp. 6199-6204
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
cDNA
Sequence and Expression of the Ceratotoxin Gene Encoding an
Antibacterial Sex-specific Peptide from the Medfly Ceratitis
capitata (diptera)
(Received for publication, November 11, 1994)
Daniela
Marchini ,
Andrea G. O.
Manetti ,
Marco
Rosetto,
Luigi F.
Bernini
,
John L.
Telford
,
Cosima
T.
Baldari,
Romano
Dallai
Ceratotoxins are antibacterial 3-kDa molecular mass amphiphilic
peptides isolated from the female reproductive accessory glands of the
medfly Ceratitis capitata. They are physiologically related to
bee melittin and show amino acid sequence homology with magainin
peptides. In this paper, we report the complete sequence of cDNA coding
for ceratotoxin A and the expression of the gene during the life cycle
of the insect. Experimental data show that the ceratotoxin is a gene
expressed exclusively in the imaginal stages and that it is
female-specific, related to sexual maturity, and stimulated by mating.
Differently from most antibacterial insect hemolymph peptides, it is
not induced by microbial infection. Western blot analysis using an
anti-ceratotoxin antibody indicates the female accessory glands as the
only site where the production of the ceratotoxin peptide occurs.

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Copyright © 1995 by the American Society for Biochemistry and Molecular Biology.
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