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(Received for publication, November 28, 1994) Alternative splicing of primary transcripts is an ubiquitous and
reversible mechanism for the generation of multiple protein isoforms
from single genes. Here we report that in cultured normal human
fibroblasts, small pH variations of the culture medium (from 7.2 to
6.9) strikingly modify the alternative splicing pattern of the
tenascin-C primary transcript. Since such extracellular pH variations
occur in many normal and pathological conditions, microenvironmental pH
may be an important element for the regulation of RNA alternative
splicing in vivo.
Volume 270,
Number 11,
Issue of March 17, 1995 pp. 6243-6245
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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