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Volume 270, Number 13, Issue of March 31, 1995 pp. 7045-7046
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
In Vivo Quantitative Characterization of Intermolecular Interactions

(Received for publication, January 5, 1995; and in revised form, February 8, 1995)

Ziv Reich,  Ellen J. Wachtel ,  Abraham Minsky

Extensive effort has been directed toward a quantitative evaluation of forces which operate between biomacromolecules since the characterization of such forces is essential to a thorough understanding of fundamental biological processes. However, all studies hitherto reported were conducted in vitro, using isolated species. Here we report the first quantitative characterization of forces operating between DNA molecules within living bacteria. Evaluation of x-ray scattering studies conducted on intact bacteria indicates that, at DNA-DNA surface separations characteristic of DNA assemblies, interactions are dominated by repulsive hydration forces which originate from the structuring of water molecules. The results support the notion that the mechanisms by means of which macromolecules function, fold, and interact with each other crucially depend upon their hydration properties.



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Copyright © 1995 by the American Society for Biochemistry and Molecular Biology.