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The B- myb gene belongs to a family of transcription
factors that also includes A- myb and c- myb. B- myb is expressed in many cell types including human neuroblastoma
cells. Here we demonstrate that B- myb expression is
down-regulated during retinoic acid-induced neural and glial
differentiation of neuroblastoma cells. This modulation is an early
event, is maintained at late times of induction, and is in part
regulated at the transcriptional level. Constitutive expression of
B- myb prevents retinoic acid-induced neural differentiation as
reflected by morphological features and the expression of (or lack of)
biochemical markers associated with the undifferentiated phenotype.
Furthermore, the expression of antisense B- myb transcripts
does not allow the rescue of viable cells, suggesting an important role
for B- myb in the survival of neuroblastoma cells. These
results indicate that B- myb plays a functional role in the
differentiative potential of neuroblastoma cells, raising the
possibility that this gene is one of the nuclear regulators in the
cascade of events leading to cellular differentiation.
Volume 270,
Number 15,
Issue of April 14, pp. 8540-8545, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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