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In a search for mutants exhibiting altered activity of the yeast
transcription factor, Mcm1, we have identified the SLN1 gene,
whose product is highly related to bacterial two-component
sensor-regulator proteins. sln1 alleles identified in our
screen increased Mcm1p-mediated transcriptional activation, while
deletion of the SLN1 locus severely reduced Mcm1p activity.
Our data establish that Mcm1p is a downstream target of the Sln1
signaling pathway. Yeast Sln1p was recently shown to be involved in
osmoregulation and to depend on the Hog1 MAP kinase (Maeda, T.,
Wurgler-Murphy, S., and Saito, H. (1994) Nature 369,
242-245). We show that SLN1-mediated regulation of Mcm1p
activity is independent of the Hog1 MAP kinase, and suggest that the
role of SLN1 is not restricted to osmoregulation.
Volume 270,
Number 15,
Issue of April 14, pp. 8739-8743, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Two-component
Regulator
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