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In a search for mutants exhibiting altered activity of the yeast
transcription factor, Mcm1, we have identified the SLN1 gene,
whose product is highly related to bacterial two-component
sensor-regulator proteins. sln1 alleles identified in our
screen increased Mcm1p-mediated transcriptional activation, while
deletion of the SLN1 locus severely reduced Mcm1p activity.
Our data establish that Mcm1p is a downstream target of the Sln1
signaling pathway. Yeast Sln1p was recently shown to be involved in
osmoregulation and to depend on the Hog1 MAP kinase (Maeda, T.,
Wurgler-Murphy, S., and Saito, H. (1994) Nature 369,
242-245). We show that SLN1-mediated regulation of Mcm1p
activity is independent of the Hog1 MAP kinase, and suggest that the
role of SLN1 is not restricted to osmoregulation.
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