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Glucose exerts inverse effects upon the secretory function of
islet
Volume 270,
Number 15,
Issue of April 14, pp. 8971-8975, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
- and
-Cells Are Correlated to Differences in Glucose Transport but Not
in Glucose Utilization
- and 
-cells, suppressing glucagon release and
increasing insulin release. This diverse action may result from
differences in glucose transport and metabolism between the two cell
types. The present study compares glucose transport in rat - and
-cells. -Cells transcribed GLUT2 and, to a lesser extent,
GLUT 1; -cells contained GLUT1 but no GLUT2 mRNA. No other
GLUT-like sequences were found among cDNAs from - or -cells.
Both cell types expressed 43-kDa GLUT1 protein which was enhanced by
culture. The 62-kDa -cell GLUT2 protein was converted to a 58-kDa
protein after trypsin treatment of the cells without detectable
consequences upon glucose transport kinetics. In -cells, the rates
of glucose transport were 10-fold higher than in -cells. In both
cell types, glucose uptake exceeded the rates of glucose utilization by
a factor of 10 or more. Glycolytic flux, measured as
D-[5
H]glucose utilization, was
comparable in - and -cells between 1 and 10 mmol/liter
substrate. In conclusion, differences in glucose transporter gene
expression between - and -cells can be correlated with
differences in glucose transport kinetics but not with different
glucose utilization rates.
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