| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
We have recently identified the protein product of the c- cbl proto-oncogene as an SH3 binding protein expressed in macrophages.
To investigate the possibility that p120
Volume 270,
Number 16,
Issue of April 21, pp. 9115-9120, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Receptors
is involved in
signaling pathways initiated by cell surface receptors for IgG
(Fc
R), lysates of HL60 cells were examined for tyrosine
phosphorylation of p120
upon Fc
R engagement. Our
findings demonstrate that p120
is tyrosine-phosphorylated
upon Fc
R engagement and that this molecule represents the major
tyrosine kinase substrate in this signaling pathway. Protein complexes
containing p120
, p72, and p56 were observed either in
resting or activated cells. In vitro studies showed that the
direct association between p120
and p56 was mediated by
the SH3 domain of p56.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Zhang, Y. J. Chiang, R. J. Hodes, and R. P. Siraganian Inactivation of c-Cbl or Cbl-b Differentially Affects Signaling from the High Affinity IgE Receptor J. Immunol., August 1, 2004; 173(3): 1811 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC Blood, August 13, 2002; 100(5): 1852 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wightman, M. S. Roberson, T. J. Lamkin, S. Varvayanis, and A. Yen Retinoic Acid-induced Growth Arrest and Differentiation: Retinoic Acid Up-Regulates CD32 (Fc{gamma}RII) Expression, the Ectopic Expression of Which Retards the Cell Cycle Mol. Cancer Ther., May 1, 2002; 1(7): 493 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Vilen, K. M. Burke, M. Sleater, and J. C. Cambier Transmodulation of BCR Signaling by Transduction- Incompetent Antigen Receptors: Implications for Impaired Signaling in Anergic B Cells J. Immunol., May 1, 2002; 168(9): 4344 - 4351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barabe, E. Rollet-Labelle, C. Gilbert, M. J. G. Fernandes, S. N. Naccache, and P. H. Naccache Early Events in the Activation of Fc{gamma}RIIA in Human Neutrophils: Stimulated Insolubilization, Translocation to Detergent-Resistant Domains, and Degradation of Fc{gamma}RIIA J. Immunol., April 15, 2002; 168(8): 4042 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Katsumata, M. Hara-Yokoyama, C. Sautes-Fridman, Y. Nagatsuka, T. Katada, Y. Hirabayashi, K. Shimizu, J. Fujita-Yoshigaki, H. Sugiya, and S. Furuyama Association of Fc{gamma}RII with Low-Density Detergent-Resistant Membranes Is Important for Cross-Linking-Dependent Initiation of the Tyrosine Phosphorylation Pathway and Superoxide Generation J. Immunol., November 15, 2001; 167(10): 5814 - 5823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Desaulniers, M. Fernandes, C. Gilbert, S. G. Bourgoin, and P. H. Naccache Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals J. Leukoc. Biol., October 1, 2001; 70(4): 659 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Scholz, K. Cartledge, and A. R. Dunn Hck Enhances the Adherence of Lipopolysaccharide-stimulated Macrophages via Cbl and Phosphatidylinositol 3-Kinase J. Biol. Chem., May 5, 2000; 275(19): 14615 - 14623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yasuda, A. Maeda, M. Kurosaki, T. Tezuka, K. Hironaka, T. Yamamoto, and T. Kurosaki Cbl Suppresses B Cell Receptor-mediated Phospholipase C (PLC)-{gamma}2 Activation by Regulating B Cell Linker Protein-PLC-{gamma}2 Binding J. Exp. Med., February 21, 2000; 191(4): 641 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sada, J. Zhang, and R. P. Siraganian Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function J. Immunol., January 1, 2000; 164(1): 338 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-K. Park, A. Erdreich-Epstein, M. Liu, K. D. Izadi, and D. L. Durden High Affinity IgG Receptor Activation of Src Family Kinases Is Required for Modulation of the Shc-Grb2-Sos Complex and the Downstream Activation of the Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase J. Immunol., December 1, 1999; 163(11): 6023 - 6034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sato, M.-K. Kim, and A. D. Schreiber Enhancement of Fc{gamma} Receptor-Mediated Phagocytosis by Transforming Mutants of Cbl J. Immunol., December 1, 1999; 163(11): 6123 - 6131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bartkiewicz, A. Houghton, and R. Baron Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl. A ROLE IN c-Cbl's TYROSINE PHOSPHORYLATION AND ITS ASSOCIATION WITH EPIDERMAL GROWTH FACTOR RECEPTOR J. Biol. Chem., October 22, 1999; 274(43): 30887 - 30895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Combs, D. E. Johnson, S. B. Cannady, T. M. Lehman, and G. E. Landreth Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of beta -Amyloid and Prion Proteins J. Neurosci., February 1, 1999; 19(3): 928 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Slavik, J. E. Hutchcroft, and B. E. Bierer CD80 and CD86 Are Not Equivalent in Their Ability to Induce the Tyrosine Phosphorylation of CD28 J. Biol. Chem., January 29, 1999; 274(5): 3116 - 3124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saci, S. Pain, F. Rendu, and C. Bachelot-Loza Fc Receptor-mediated Platelet Activation Is Dependent on Phosphatidylinositol 3-Kinase Activation and Involves p120cbl J. Biol. Chem., January 22, 1999; 274(4): 1898 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hunter, E. A. Burton, S. C. Wu, and S. M. Anderson Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase J. Biol. Chem., January 22, 1999; 274(4): 2097 - 2106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Lupher Jr., N. Rao, N. L. Lill, C. E. Andoniou, S. Miyake, E. A. Clark, B. Druker, and H. Band Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase. A CRITICAL ROLE FOR Cbl PHOSPHOTYROSINE-BINDING DOMAIN BINDING TO Syk PHOSPHOTYROSINE 323 J. Biol. Chem., December 25, 1998; 273(52): 35273 - 35281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Kyono, R. de Jong, R. Kil Park, Y. Liu, N. Heisterkamp, J. Groffen, and D. L. Durden Differential Interaction of Crkl with Cbl or C3G, Hef-1, and {gamma} Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (Fc{gamma}RI) J. Immunol., November 15, 1998; 161(10): 5555 - 5563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Murphy, R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello, C. B. F. Thien, W. Y. Langdon, and D. D. L. Bowtell Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice Mol. Cell. Biol., August 1, 1998; 18(8): 4872 - 4882. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. Park, W. T. Kyono, Y. Liu, and D. L. Durden CBL-GRB2 Interaction in Myeloid Immunoreceptor Tyrosine Activation Motif Signaling J. Immunol., May 15, 1998; 160(10): 5018 - 5027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Feshchenko, W. Y. Langdon, and A. Y. Tsygankov Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells J. Biol. Chem., April 3, 1998; 273(14): 8323 - 8331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Barabé, C. Gilbert, N. Liao, S. G. Bourgoin, and P. H. Naccache Crystal-induced neutrophil activation VI. Involvement of Fc{gamma}RIIIB (CD16) and CD11b in response to inflammatory microcrystals FASEB J, February 1, 1998; 12(2): 209 - 220. [Abstract] [Full Text]
|
|
|
|
|
|
D. Linnekin, C. S. DeBerry, and S. Mou Lyn Associates with the Juxtamembrane Region of c-Kit and Is Activated by Stem Cell Factor in Hematopoietic Cell Lines and Normal Progenitor Cells J. Biol. Chem., October 24, 1997; 272(43): 27450 - 27455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Fixman, M. Holgado-Madruga, L. Nguyen, D. M. Kamikura, T. M. Fournier, A. J. Wong, and M. Park Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1 J. Biol. Chem., August 8, 1997; 272(32): 20167 - 20172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hunter, B. L. Koch, and S. M. Anderson Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3-Kinase Mol. Endocrinol., August 1, 1997; 11(9): 1213 - 1222. [Abstract] [Full Text]
|
|
|
|
|
|
M. Sattler, R. Salgia, G. Shrikhande, S. Verma, N. Uemura, S. F. Law, E. A. Golemis, and J. D. Griffin Differential Signaling after beta 1 Integrin Ligation Is Mediated Through Binding of CRKL to p120CBL and p110HEF1 J. Biol. Chem., May 30, 1997; 272(22): 14320 - 14326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Polgar, J. M. Clemetson, B. E. Kehrel, M. Wiedemann, E. M. Magnenat, T. N. C. Wells, and K. J. Clemetson Platelet Activation and Signal Transduction by Convulxin, a C-type Lectin from Crotalus durissus terrificus (Tropical Rattlesnake) Venom via the p62/GPVI Collagen Receptor J. Biol. Chem., May 23, 1997; 272(21): 13576 - 13583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Barber, J. M. Mason, T. Fukazawa, K. A. Reedquist, B. J. Druker, H. Band, and A. D. D'Andrea Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins Blood, May 1, 1997; 89(9): 3166 - 3174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sattler, R. Salgia, G. Shrikhande, S. Verma, E. Pisick, K. V.S. Prasad, and J. D. Griffin Steel Factor Induces Tyrosine Phosphorylation of CRKL and Binding of CRKL to a Complex Containing c-Kit, Phosphatidylinositol 3-Kinase, and p120CBL J. Biol. Chem., April 11, 1997; 272(15): 10248 - 10253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Fitzer-Attas, D. G. Schindler, T. Waks, and Z. Eshhar Direct T Cell Activation by Chimeric Single Chain Fv-Syk Promotes Syk-Cbl Association and Cbl Phosphorylation J. Biol. Chem., March 28, 1997; 272(13): 8551 - 8557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ueno, K. Sasaki, K. Miyagawa, H. Honda, K. Mitani, Y. Yazaki, and H. Hirai Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling J. Biol. Chem., March 28, 1997; 272(13): 8739 - 8743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ojaniemi, S. S. Martin, F. Dolfi, J. M. Olefsky, and K. Vuori The Proto-oncogene Product p120cbl Links c-Src and Phosphatidylinositol 3'-Kinase to the Integrin Signaling Pathway J. Biol. Chem., February 7, 1997; 272(6): 3780 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Anderson, E. A. Burton, and B. L. Koch Phosphorylation of Cbl following Stimulation with Interleukin-3 and Its Association with Grb2, Fyn, and Phosphatidylinositol 3-Kinase J. Biol. Chem., January 10, 1997; 272(2): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Liu, C. Elly, W. Y. Langdon, and A. Altman Ras-dependent, Ca2+-stimulated Activation of Nuclear Factor of Activated T Cells by a Constitutively Active Cbl Mutant in T Cells J. Biol. Chem., January 3, 1997; 272(1): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Tsygankov, S. Mahajan, J. E. Fincke, and J. B. Bolen Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells J. Biol. Chem., October 25, 1996; 271(43): 27130 - 27137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
JeraldA. Donovan, Y. Ota, WallaceY. Langdon, and LawrenceE. Samelson Regulation of the Association of p120cbl with Grb2 in Jurkat T Cells J. Biol. Chem., October 18, 1996; 271(42): 26369 - 26374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Lupher Jr., K. A. Reedquist, S. Miyake, W. Y. Langdon, and H. Band A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells J. Biol. Chem., September 27, 1996; 271(39): 24063 - 24068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cox, P. Chang, T. Kurosaki, and S. Greenberg Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly J. Biol. Chem., July 12, 1996; 271(28): 16597 - 16602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fukazawa, S. Miyake, V. Band, and H. Band Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins J. Biol. Chem., June 14, 1996; 271(24): 14554 - 14559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Reedquist, T. Fukazawa, G. Panchamoorthy, W. Y. Langdon, S. E. Shoelson, B. J. Druker, and H. Band Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G J. Biol. Chem., April 5, 1996; 271(14): 8435 - 8442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Panchamoorthy, T. Fukazawa, S. Miyake, S. Soltoff, K. Reedquist, B. Druker, S. Shoelson, L. Cantley, and H. Band p120[IMAGE] Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase J. Biol. Chem., February 9, 1996; 271(6): 3187 - 3194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kontani, I. Kukimoto, H. Nishina, S.-i. Hoshino, O. Hazeki, Y. Kanaho, and T. Katada Tyrosine Phosphorylation of the c-cbl Proto-oncogene Product Mediated by Cell Surface Antigen CD38 in HL-60 Cells J. Biol. Chem., January 19, 1996; 271(3): 1534 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, Y.-G. Yeung, W. Y. Langdon, and E. R. Stanley c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages J. Biol. Chem., January 5, 1996; 271(1): 17 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Kim, Y.-T. Kim, and S. Pillai Association of Activated Phosphatidylinositol 3-Kinase with p120[IMAGE] in Antigen Receptor-ligated B Cells J. Biol. Chem., November 27, 1995; 270(46): 27504 - 27509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fukazawa, K. A. Reedquist, T. Trub, S. Soltoff, G. Panchamoorthy, B. Druker, L. Cantley, S. E. Shoelson, and H. Band The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 J. Biol. Chem., August 11, 1995; 270(32): 19141 - 19150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nguyen, C. V. Ramana, J. Bayes, and G. R. Stark Roles of Phosphatidylinositol 3-Kinase in Interferon-gamma -dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression J. Biol. Chem., August 31, 2001; 276(36): 33361 - 33368. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
