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Previous observations have shown that binding of growth hormone
to its receptor leads to activation of transcription factors via a
mechanism involving phosphorylation on tyrosine residues. In order to
establish whether the prolactin-activated transcription factor Stat 5
(mammary gland factor) is also activated by growth hormone, nuclear
extracts were prepared from COS-7 cells transiently expressing
transfected Stat 5 and growth hormone receptor cDNA. Gel
electrophoresis mobility shift analyses revealed the growth
hormone-dependent presence of specific DNA-binding proteins in these
extracts. The complexes formed could be supershifted by polyclonal
anti-Stat 5 antiserum. In other experiments nuclear extracts from
growth hormone-treated Chinese hamster ovary cells stably expressing
transfected growth hormone receptor cDNA and liver from growth
hormone-treated hypophysectomized rats were used for gel
electrophoresis mobility shift analyses. These also revealed the
presence of specific DNA-binding proteins sharing antigenic
determinants with Stat 5. Stat 5 cDNA was shown to be capable of
complementing the growth hormone-dependent activation of transcription
of a reporter gene in the otherwise unresponsive COS-7 cell line. This
complementation was dependent on the presence of Stat 5 tyrosine 694,
suggesting a role for phosphorylation of this residue in growth
hormone-dependent activation of DNA-binding and transcription.
Volume 270,
Number 16,
Issue of April 21, pp. 9448-9453, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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E. Pfitzner, R. Jähne, M. Wissler, E. Stoecklin, and B. Groner p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response Mol. Endocrinol., October 1, 1998; 12(10): 1582 - 1593. [Abstract] [Full Text]
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T. Zhu, E. L. K. Goh, and P. E. Lobie Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2. FAK IS NOT REQUIRED FOR STAT-MEDIATED TRANSCRIPTION J. Biol. Chem., April 24, 1998; 273(17): 10682 - 10689. [Abstract] [Full Text] [PDF]
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L. Fernandez, A. Flores-Morales, O. Lahuna, D. Sliva, G. Norstedt, L.-A. Haldosen, A. Mode, and J.-A. Gustafsson Desensitization of the Growth Hormone-Induced Janus Kinase 2 (Jak 2)/Signal Transducer and Activator of Transcription 5 (Stat5)-Signaling Pathway Requires Protein Synthesis and Phospholipase C Endocrinology, April 1, 1998; 139(4): 1815 - 1824. [Abstract] [Full Text] [PDF]
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S.-O. Kim, J. Jiang, W. Yi, G.-S. Feng, and S. J. Frank Involvement of the Src Homology 2-containing Tyrosine Phosphatase SHP-2 in Growth Hormone Signaling J. Biol. Chem., January 23, 1998; 273(4): 2344 - 2354. [Abstract] [Full Text] [PDF]
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J. S. Freeth, C. M. Silva, A. J. Whatmore, and P. E. Clayton Activation of the Signal Transducers and Activators of Transcription Signaling Pathway by Growth Hormone (GH) in Skin Fibroblasts from Normal and GH Binding Protein-Positive Laron Syndrome Children Endocrinology, January 1, 1998; 139(1): 20 - 28. [Abstract] [Full Text] [PDF]
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G. Luo and L.-y. Yu-Lee Transcriptional Inhibition by Stat5. DIFFERENTIAL ACTIVITIES AT GROWTH-RELATED VERSUS DIFFERENTIATION-SPECIFIC PROMOTERS J. Biol. Chem., October 24, 1997; 272(43): 26841 - 26849. [Abstract] [Full Text] [PDF]
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E. L. K. Goh, T. J. Pircher, T. J. J. Wood, G. Norstedt, R. Graichen, and P. E. Lobie Growth Hormone-Induced Reorganization of the Actin Cytoskeleton Is Not Required for STAT5 (Signal Transducer and Activator of Transcription-5)-Mediated Transcription Endocrinology, August 1, 1997; 138(8): 3207 - 3215. [Abstract] [Full Text] [PDF]
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L. S. Smit, J. A. VanderKuur, A. Stimage, Y. Han, G. Luo, L.-y. Yu-Lee, J. Schwartz, and C. Carter-Su Growth Hormone-Induced Tyrosyl Phosphorylation and Deoxyribonucleic Acid Binding Activity of Stat5A and Stat5B Endocrinology, August 1, 1997; 138(8): 3426 - 3434. [Abstract] [Full Text] [PDF]
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K. K. Kuropatwinski, C. De Imus, D. Gearing, H. Baumann, and B. Mosley Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6 J. Biol. Chem., June 13, 1997; 272(24): 15135 - 15144. [Abstract] [Full Text] [PDF]
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G. T. Ooi, F. J. Cohen, L. Y.-H. Tseng, M. M. Rechler, and Y. R. Boisclair Growth Hormone Stimulates Transcription of the Gene Encoding the Acid-Labile Subunit (ALS) of the Circulating Insulin-Like Growth Factor-Binding Protein Complex and ALS Promoter Activity in Rat Liver Mol. Endocrinol., June 1, 1997; 11(7): 997 - 1007. [Abstract] [Full Text]
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C. A. Gebert, S.-H. Park, and D. J. Waxman Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation Mol. Endocrinol., April 1, 1997; 11(4): 400 - 414. [Abstract] [Full Text]
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M. Sundstrom, T. Lundqvist, J. Rodin, LutzB. Giebel, D. Milligan, and G. Norstedt Crystal Structure of an Antagonist Mutant of Human Growth Hormone, G120R, in Complex with Its Receptor at 2.9AResolution J. Biol. Chem., December 13, 1996; 271(50): 32197 - 32203. [Abstract] [Full Text] [PDF]
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D. J. Waxman, S. Zhao, and H. K. Choi Interaction of a Novel Sex-dependent, Growth Hormone-regulated Liver Nuclear Factor with CYP2C12 Promoter J. Biol. Chem., November 22, 1996; 271(47): 29978 - 29987. [Abstract] [Full Text] [PDF]
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B. C. Xu, X. Wang, C. J. Darus, and J. J. Kopchick Growth Hormone Promotes the Association of Transcription Factor STAT5 with the Growth Hormone Receptor J. Biol. Chem., August 16, 1996; 271(33): 19768 - 19773. [Abstract] [Full Text] [PDF]
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P. A. Ram, S.-H. Park, H. K. Choi, and D. J. Waxman Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver J. Biol. Chem., March 8, 1996; 271(10): 5929 - 5940. [Abstract] [Full Text] [PDF]
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P. L. Bergad, H.-M. Shih, H. C. Towle, S. J. Schwarzenberg, and S. A. Berry Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two [IMAGE]-Activated Sites J. Biol. Chem., October 20, 1995; 270(42): 24903 - 24910. [Abstract] [Full Text] [PDF]
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C.-F. Lai, J. Ripperger, |
