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Adenovirus (Ad) genome DNA is complexed with viral core proteins
in the virus particle and in host cells during the early stages of
infection. This DNA protein complex, called Ad core, is thought to be
the template for transcription and DNA replication in infected cells.
The Ad core functioned as template for DNA replication in the cell-free
system consisting of viral replication proteins, uninfected HeLa
nuclear extracts, and a novel factor, template activating factor-I
(TAF-I) that we have isolated from uninfected HeLa cytoplasmic
fractions. The Ad core did not function as an efficient template in the
cell-free transcription system with nuclear extracts of uninfected HeLa
cells. The addition of TAF-I resulted in the stimulation of
transcription from E1A and ML promoters on the Ad core. TAF-I was
required, at least, for the formation of preinitiation complexes. These
observations suggest that, in addition to factors essential for
transcription on naked DNA template, the factor such as TAF-I needed
for replication of the Ad core is also required for transcription from
the Ad genome in a chromatin-like structure.
Volume 270,
Number 16,
Issue of April 21, pp. 9645-9650, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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