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Nucleotide sequence analysis of six independently isolated cDNAs
for rat acyl-CoA synthetase (ACS) revealed three forms of ACS mRNA,
designated form-A, -B, and -C mRNAs, which differ in their
5`-untranslated regions. Form-A mRNA was preferentially detected in
normal and peroxisome-induced livers, whereas form-B mRNA was found in
peroxisome-induced livers but not in normal livers and hearts, and
form-C mRNA was preferentially found in normal hearts and
peroxisome-induced livers. Analysis of two overlapping genomic clones
for the rat ACS gene revealed that the three 5`-untranslated regions of
the mRNAs are individually encoded by three different exons located
within a 20-kilobase genomic fragment. The transcription start sites of
the three forms of ACS mRNA were determined and nucleotide sequences of
5`-upstream regions of the three 5`-end exons were determined. The
5`-upstream regions were fused to the chloramphenicol acetyltransferase
gene and transcription units of the three forms of ACS mRNAs were
determined. These data indicate that the three forms of ACS mRNA with
5`-end heterogeneity are generated by alternative transcription from
three promoters in the rat ACS gene.
Volume 270,
Number 16,
Issue of April 21, pp. 9676-9682, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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