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Cultured cells of various origins have been shown to be
surrounded by a hyaluronan-containing coat, a structure that can be
visualized by its ability to exclude large particles such as
erythrocytes. When cultured in medium with no or low concentrations of
serum, the cells lose their coats, although they still produce
hyaluronan; upon the addition of serum, the coats are formed again.
Here, we show that the serum protein inter-
Volume 270,
Number 17,
Issue of April 28, pp. 9698-9701, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
-inhibitor
Is Required for the Formation of the Hyaluronan-containing Coat on
Fibroblasts and Mesothelial Cells
-inhibitor can replace
whole serum as an inducer of the formation of the coats on fibroblasts
and mesothelial cells. The physiological role of inter--inhibitor
has so far been unclear; our findings, together with those obtained
with cumulus cell-oocyte complexes (Chen, L., Mao, S. J., and Larsen,
W. J. (1992) J. Biol. Chem. 267, 12380-12386), suggest
that inter--inhibitor and related proteins have a general function
as stabilizers of hyaluronan-containing pericellular coats.
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