|
|
|
|||||||
|
|||||||||
We have shown that interleukin-1 (IL-1) and IL-2 control IL-2
receptor
Transient transfection experiments show that several
elements in the promoter-proximal region of the IL-2R
Volume 270,
Number 18,
Issue of May 5, pp. 10743-10753, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Gene Expression
INTERLEUKIN-1 AND INTERLEUKIN-2 CONTROL TRANSCRIPTION VIA DISTINCT
cis-ACTING ELEMENTS
(IL-2R) gene transcription in
CD4CD8
murine T lymphocyte
precursors. Here we map the cis-acting elements that mediate
interleukin responsiveness of the mouse IL-2R
gene using a thymic
lymphoma-derived hybridoma (PC60). The transcriptional response of the
IL-2R gene to stimulation by IL-1 + IL-2 is biphasic. IL-1
induces a rapid, protein synthesis-independent appearance of IL-2R
mRNA that is blocked by inhibitors of NF-
B activation. It also
primes cells to become IL-2 responsive and thereby prepares the second
phase, in which IL-2 induces a 100-fold further increase in IL-2R
transcripts.
gene
contribute to IL-1 responsiveness, most importantly an NF-B site
conserved in the human and mouse gene. IL-2 responsiveness, on the
other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream
of the major transcription start site. This segment functions as an
IL-2-inducible enhancer and lies within a region that becomes DNase I
hypersensitive in normal T cells in which IL-2R expression has
been induced. IL-2 responsiveness requires three distinct elements
within the enhancer. Two of these are potential binding sites for STAT
proteins.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H.-P. Kim, B.-G. Kim, J. Letterio, and W. J. Leonard Smad-dependent Cooperative Regulation of Interleukin 2 Receptor {alpha} Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-{beta} J. Biol. Chem., October 7, 2005; 280(40): 34042 - 34047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O'Sullivan, H.-C. Chang, Q. Yu, and M. H. Kaplan STAT4 Is Required for Interleukin-12-induced Chromatin Remodeling of the CD25 Locus J. Biol. Chem., February 20, 2004; 279(8): 7339 - 7345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Kovanen, A. Rosenwald, J. Fu, E. M. Hurt, L. T. Lam, J. M. Giltnane, G. Wright, L. M. Staudt, and W. J. Leonard Analysis of gamma c-Family Cytokine Target Genes. IDENTIFICATION OF DUAL-SPECIFICITY PHOSPHATASE 5 (DUSP5) AS A REGULATOR OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN INTERLEUKIN-2 SIGNALING J. Biol. Chem., February 7, 2003; 278(7): 5205 - 5213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Yeh, S. Spicuglia, S. Kumar, A. Sanchez-Sevilla, P. Ferrier, and J. Imbert Control of IL-2R{alpha} gene expression: structural changes within the proximal enhancer/core promoter during T-cell development Nucleic Acids Res., May 1, 2002; 30(9): 1944 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Han, S. H. Park, Y. J. Jeon, Y. K. Kim, H. M. Kim, and K. H. Yang Prodigiosin Blocks T Cell Activation by Inhibiting Interleukin-2Ralpha Expression and Delays Progression of Autoimmune Diabetes and Collagen-Induced Arthritis J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 415 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Yeh, P. Lecine, J. A. Nunes, S. Spicuglia, P. Ferrier, D. Olive, and J. Imbert Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor {alpha}-Chain Locus Mol. Cell. Biol., July 15, 2001; 21(14): 4515 - 4527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Utting, J. J. Priatel, S.-J. Teh, and H.-S. Teh p59fyn (Fyn) Promotes the Survival of Anergic CD4-CD8- {{alpha}}{{beta}} TCR+ Cells but Negatively Regulates Their Proliferative Response to Antigen Stimulation J. Immunol., February 1, 2001; 166(3): 1540 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Lee, S. L. Camhi, B. Y. Chin, J. Alam, and A. M. K. Choi AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1 Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L175 - L182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, I. Scordi, M. J. Smyth, and M. G. Lichtenheld Interleukin 2 Receptor Signaling Regulates the Perforin Gene through Signal Transducer and Activator of Transcription (Stat)5 Activation of Two Enhancers J. Exp. Med., November 1, 1999; 190(9): 1297 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Aman, T.-S. Migone, A. Sasaki, D. P. Ascherman, M.-h. Zhu, E. Soldaini, K. Imada, A. Miyajima, A. Yoshimura, and W. J. Leonard CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits Interleukin-2-dependent Signaling J. Biol. Chem., October 15, 1999; 274(42): 30266 - 30272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Friedrich, W. Kammer, I. Erhardt, S. Brandlein, W. Sebald, and R. Moriggl Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation Int. Immunol., August 1, 1999; 11(8): 1283 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rusterholz, P. C. Henrioud, and M. Nabholz Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha Gene to Transcription Factors Mol. Cell. Biol., April 1, 1999; 19(4): 2681 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Herblot, P. Chastagner, L. Samady, J.-L. Moreau, C. Demaison, P. Froussard, X. Liu, J. Bonnet, and J. Theze IL-2-Dependent Expression of Genes Involved in Cytoskeleton Organization, Oncogene Regulation, and Transcriptional Control J. Immunol., March 15, 1999; 162(6): 3280 - 3288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. John, U. Vinkemeier, E. Soldaini, J. E. Darnell Jr., and W. J. Leonard The Significance of Tetramerization in Promoter Recruitment by Stat5 Mol. Cell. Biol., March 1, 1999; 19(3): 1910 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 417 - 424. [Abstract] [PDF]
|
|
|
|
|
|
K. Imada, E. T. Bloom, H. Nakajima, J. A. Horvath-Arcidiacono, G. B. Udy, H. W. Davey, and W. J. Leonard Stat5b Is Essential for Natural Killer Cell-mediated Proliferation and Cytolytic Activity J. Exp. Med., December 7, 1998; 188(11): 2067 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K.-H. Meyer, P. Reichenbach, U. Schindler, E. Soldaini, and M. Nabholz Interaction of STAT5 Dimers on Two Low Affinity Binding Sites Mediates Interleukin 2 (IL-2) Stimulation of IL-2 Receptor alpha Gene Transcription J. Biol. Chem., December 12, 1997; 272(50): 31821 - 31828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Serdobova, M. Pla, P. Reichenbach, P. Sperisen, J. Ghysdael, A. Wilson, J. Freeman, and M. Nabholz Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2-responsive Enhancer in the Mouse IL-2 Receptor alpha Gene J. Exp. Med., April 7, 1997; 185(7): 1211 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Ascherman, T.-S. Migone, M. C. Friedmann, and W. J. Leonard Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor alpha Chain Gene. CRITICAL ROLE OF TWO FUNCTIONALLY REDUNDANT TYROSINE RESIDUES IN THE IL-2 RECEPTOR beta CHAIN CYTOPLASMIC DOMAIN AND SUGGESTION THAT THESE RESIDUES MEDIATE MORE THAN STAT5 ACTIVATION J. Biol. Chem., March 28, 1997; 272(13): 8704 - 8709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Santee and L. B. Owen-Schaub Human Tumor Necrosis Factor Receptor p75/80 (CD120b) Gene Structure and Promoter Characterization J. Biol. Chem., August 30, 1996; 271(35): 21151 - 21159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Soldaini, M. Pla, F. Beermann, E. Espel, P. Corthésy, S. Barangé, G. A. Waanders, H. R. MacDonald, and M. Nabholz Mouse Interleukin-2 Receptor [IMAGE] Gene Expression J. Biol. Chem., May 5, 1995; 270(18): 10733 - 10742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Ehret, P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES J. Biol. Chem., February 23, 2001; 276(9): 6675 - 6688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kulms and T. Schwarz Ultraviolet Radiation Inhibits Interleukin-2-induced Tyrosine Phosphorylation and the Activation of STAT5 in T Lymphocytes J. Biol. Chem., April 13, 2001; 276(16): 12849 - 12855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Conze, T. Krahl, N. Kennedy, L. Weiss, J. Lumsden, P. Hess, R. A. Flavell, G. Le Gros, R. J. Davis, and M. Rincon c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation J. Exp. Med., March 25, 2002; 195(7): 811 - 823. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |