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Antibodies against the four isoforms of the human plasma
membrane Ca
The tissue distribution of the
four isoforms was estimated by Western blot analysis. Two, PMCA1 and
PMCA4, were expressed in all tissues tested (with the exception of the
choroid plexus, where the former was not detected). In most tissues the
signal from the PMCA1 protein exceeded that of PMCA4, the exception
being the erythrocyte. The PMCA2 and PMCA3 proteins were only found in
neuronal tissues; the PMCA2 protein was present in high concentrations
in the cerebellum and in the cerebral cortex. At variance with previous
results on mRNA (e.g. the kidney) no other tissues contained
the PMCA2 protein. PMCA3 was the other tissue-specific isoform; in
agreement with results in the rat, the protein was found in human
neuronal tissues, particularly in the choroid plexus, but was
practically absent in all other tissues tested.
Volume 270,
Number 20,
Issue of May 19, pp. 12184-12190, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Pump
A STUDY USING SPECIFIC ANTIBODIES
-ATPase (PMCA) were raised using an
N-terminal sequence of the pump as epitope. The antibodies against PMCA
isoforms 1, 2, and 3 were not species-specific, e.g. they also
recognized the corresponding proteins in rat, whereas that against the
human PMCA isoform 4 failed to do so.
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