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The myelin basic protein (MBP) gene is expressed only in
oligodendrocytes and Schwann cells, and expression follows a tightly
regulated developmental time course. Cell type- and developmental
stage-specific expression of the MBP gene appears to be regulated by a
series of cis-acting elements located upstream of the transcription
start site. The proximal element of the MBP regulatory region (MB1),
located between nucleotides -14 and -50, is one of several
elements participating in the programmed expression of MBP. In this
report, we describe the molecular cloning and characterization of
myelin gene expression factor-2 (Myef-2), a protein isolated from mouse
brain that binds specifically to single-stranded DNA derived from the
MB1 element and represses transcription of the MBP gene in transient
transfection assay. Myef-2 mRNA is developmentally regulated in mouse
brain; its peak expression occurs at postnatal day 7, prior to the
onset of MBP expression. The developmental pattern of Myef-2 mRNA
expression coincides with that previously described for SCIP, a POU
domain transcription factor that also represses myelin basic protein
expression. The myef-2 gene maps to mouse chromosome 2. The
relevance of these findings for regulation of MBP gene expression and
oligodendrocyte differentiation is discussed.
Volume 270,
Number 21,
Issue of May 26, pp. 12503-12510, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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