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Volume 270, Number 21, Issue of May 26, pp. 12787-12793, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.

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The M 35,000 -Adrenergic Receptor mRNA-binding Protein Binds Transcripts of G-protein-linked Receptors Which Undergo Agonist-induced Destabilization

Baby G. Tholanikunnel , James G. Granneman , Craig C. Malbon

The M 35,000 -adrenergic receptor mRNA-binding protein, termed -ARB protein, is induced by -adrenergic agonists and binds to -receptor mRNAs that display agonist-induced destabilization. Recently a cognate sequence in the mRNA was identified that provides for recognition by -ARB protein. In the present work we test the ability of the -ARB to discriminate among G-protein-linked receptor mRNAs that either do or do not display agonist-induced destabilization and test the predictive value of the presence of the cognate sequence to identify receptors displaying post-transcriptional regulation. Transcripts of -, but not rat -, rat -, or human -adrenergic receptors bind -ARB protein, linking agonist-induced destabilization of mRNA to transcripts with the cognate sequence. Scanning GeneBank for G-protein-linked receptor transcripts with the cognate sequence revealed several candidates, including the thrombin receptor. We demonstrate that the thrombin receptor mRNA is recognized by -ARB protein and like the -receptor is regulated post-transcriptionally by agonist and cAMP. Thus, the domain of regulation by -ARB protein includes transcripts of G-protein-linked receptors other than -adrenergic receptors.

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