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Volume 270, Number 22, Issue of June 2, pp. 13262-13270, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein
PROPOSED ROLE AS AN INTRACELLULAR REGULATOR OF MALE-SPECIFIC LIVER GENE TRANSCRIPTION

David J. Waxman , Prabha A. Ram , Soo-Hee Park , Hee K. Choi

Growth hormone (GH) exerts sexually dimorphic effects on liver gene transcription that are regulated by the temporal pattern of pituitary GH release, which is intermittent in male rats and nearly continuous in females. To investigate the influence of these GH secretory patterns on intracellular hepatocyte signaling, we compared the pattern of liver nuclear protein tyrosine phosphorylation in male and female rats. An M 93,000 polypeptide, p93, was found to be tyrosine phosphorylated to a high level in male but not female rats. GH, but not prolactin, rapidly stimulated p93 tyrosine phosphorylation in hypophysectomized rats. Intermittent plasma GH pulses triggered repeated p93 phosphorylation, while continuous GH exposure led to desensitization and a dramatic decline in liver nuclear p93. p93 was cross-reactive with two monoclonal antibodies raised to mammary Stat 5, whose tyrosine phosphorylation is stimulated by prolactin. Intermittent GH pulsation translocated liver Stat 5/p93 protein from the cytosol to the nucleus and also activated its DNA binding activity, as demonstrated using a mammary Stat 5-binding DNA element derived from the -casein gene. p93 is thus a liver-expressed, Stat 5-related DNA binding protein that undergoes tyrosine phosphorylation and nuclear translocation in response to intermittent plasma GH stimulation and is proposed to be an intracellular mediator of the stimulatory effects of GH pulses on male-specific liver gene expression.



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Home page
 J. Biol. Chem.Home page
T. Zhu, E. L. K. Goh, and P. E. Lobie
Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2. FAK IS NOT REQUIRED FOR STAT-MEDIATED TRANSCRIPTION
J. Biol. Chem., April 24, 1998; 273(17): 10682 - 10689.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
L. Fernandez, A. Flores-Morales, O. Lahuna, D. Sliva, G. Norstedt, L.-A. Haldosen, A. Mode, and J.-A. Gustafsson
Desensitization of the Growth Hormone-Induced Janus Kinase 2 (Jak 2)/Signal Transducer and Activator of Transcription 5 (Stat5)-Signaling Pathway Requires Protein Synthesis and Phospholipase C
Endocrinology, April 1, 1998; 139(4): 1815 - 1824.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Gevers, S. M. Pincus, I. C. A. F. Robinson, and J. D. Veldhuis
Differential orderliness of the GH release process in castrate male and female rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R437 - R444.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Wang, S. E. Wolf, and B. M. Evers
Differential activation of the Stat signaling pathway in the liver after burn injury
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1153 - G1159.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. A. Ram and D. J. Waxman
Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase
J. Biol. Chem., July 11, 1997; 272(28): 17694 - 17702.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. B. Udy, R. P. Towers, R. G. Snell, R. J. Wilkins, S.-H. Park, P. A. Ram, D. J. Waxman, and H. W. Davey
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
PNAS, July 8, 1997; 94(14): 7239 - 7244.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. K. Kuropatwinski, C. De Imus, D. Gearing, H. Baumann, and B. Mosley
Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6
J. Biol. Chem., June 13, 1997; 272(24): 15135 - 15144.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
C. A. Gebert, S.-H. Park, and D. J. Waxman
Regulation of Signal Transducer and Activator of Transcription (STAT) 5b Activation by the Temporal Pattern of Growth Hormone Stimulation
Mol. Endocrinol., April 1, 1997; 11(4): 400 - 414.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
S. A. Nelson and D. M. Robins
Two Distinct Mechanisms Elicit Androgen-Dependent Expression of the Mouse Sex-Limited Protein Gene
Mol. Endocrinol., April 1, 1997; 11(4): 460 - 469.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
D. J. Waxman, S. Zhao, and H. K. Choi
Interaction of a Novel Sex-dependent, Growth Hormone-regulated Liver Nuclear Factor with CYP2C12 Promoter
J. Biol. Chem., November 22, 1996; 271(47): 29978 - 29987.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Kordula, J. Ripperger, K. K. Morella, J. Travis, and H. Baumann
Two Separate Signal Transducer and Activator of Transcription Proteins Regulate Transcription of the Serine Proteinase Inhibitor-3 Gene in Hepatic Cells
J. Biol. Chem., March 22, 1996; 271(12): 6752 - 6757.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. A. Ram, S.-H. Park, H. K. Choi, and D. J. Waxman
Growth Hormone Activation of Stat 1, Stat 3, and Stat 5 in Rat Liver
J. Biol. Chem., March 8, 1996; 271(10): 5929 - 5940.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. A. Ripperger, S. Fritz, K. Richter, G. M. Hocke, F. Lottspeich, and G. H. Fey
Transcription Factors Stat3 and Stat5b Are Present in Rat Liver Nuclei Late in an Acute Phase Response and Bind Interleukin-6 Response Elements
J. Biol. Chem., December 15, 1995; 270(50): 29998 - 30006.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Delesque-Touchard, S.-H. Park, and D. J. Waxman
Synergistic Action of Hepatocyte Nuclear Factors 3 and 6 on CYP2C12 Gene Expression and Suppression by Growth Hormone-activated STAT5b. PROPOSED MODEL FOR FEMALE-SPECIFIC EXPRESSION OF CYP2C12 IN ADULT RAT LIVER
J. Biol. Chem., October 27, 2000; 275(44): 34173 - 34182.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. A. Ram and D. J. Waxman
Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone
J. Biol. Chem., December 8, 2000; 275(50): 39487 - 39496.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. M. Gowri, T. C. Ganguly, J. Cao, M. N. Devalaraja, B. Groner, and M. Vore
Conversion of Threonine 757 to Valine Enhances Stat5a Transactivation Potential
J. Biol. Chem., March 23, 2001; 276(13): 10485 - 10491.
[Abstract] [Full Text] [PDF]


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