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Mice that are homozygous for the targeted disruption of the gene
encoding the B
Volume 270,
Number 23,
Issue of June 9, pp. 13706-13710, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Bradykinin Receptor Gene in Mice
Eliminates Bradykinin Action in Smooth Muscle and Neurons
bradykinin receptor have been generated. The
gene disruption results in a deletion of the entire coding sequence for
the B receptor. The disruption of the B receptor gene has been confirmed by genetic, biochemical, and
pharmacological analyses. Mice that are homozygous for the disruption
of the B receptor gene are fertile and indistinguishable
from their littermates by visual inspection. Bradykinin fails to
produce responses in pharmacological preparations from ileum, uterus,
and the superior cervical ganglia from these mice. Therefore,
expression of a single gene appears to be responsible for conferring
responsiveness to bradykinin in these tissues.
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