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Volume 270, Number 24, Issue of June 16, pp. 14517-14522, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors

Alessandra Pernis , Sanjay Gupta , James Yopp , Evan Garfein , Helena Kashleva , Chris Schindler , Paul Rothman

The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common () chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the -associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.




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