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The IL-2, IL-4, and IL-7 signaling pathways have been shown to
utilize shared components. The receptors for these cytokines are
composed of ligand-specific binding chains that associate with a shared
signaling subunit, the common
Volume 270,
Number 24,
Issue of June 16, pp. 14517-14522, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Chain-associated Cytokine Receptors Signal through Distinct Transducing
Factors
(
) chain. In
addition, IL-2, IL-4, and IL-7 induce activation of a common set of
nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further
investigated the signaling events induced by these cytokines and find
that the -associated receptors activate distinct
signal transducing factors (STFs). In addition, we show that a 94-kDa
STAT-related protein (p94) is activated in response to IL-2 and IL-7,
but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate
distinct signaling molecules which might be differentially recruited to
the receptor complex by the ligand-specific units of the IL-2, IL-4,
and IL-7 receptors.
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