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We report cDNA cloning and characterization of the human and
mouse orthologs of the chicken YAP (Yes-associated protein) gene which
encodes a novel protein that binds to the SH3 (Src homology 3) domain
of the Yes proto-oncogene product. Sequence comparison between mouse,
human, and chicken YAP proteins showed an inserted sequence in the
mouse YAP that represented an imperfect repeat of an upstream sequence.
Further analysis of this sequence revealed a putative protein module
that is found in various structural, regulatory, and signaling
molecules in yeast, nematode, and mammals including human dystrophin.
Because one of the prominent features of this sequence motif is two
tryptophans (W), we named it the WW domain (Bork, P., and Sudol, M.
(1994) Trends Biochem. Sci. 19, 531-533). Since its
delineation, more proteins have been shown to contain this domain, and
we report here on the widespread distribution of the WW module and
present a discussion of its possible function. We have also shown that
the human YAP gene is well conserved among higher eukaryotes, but it
may not be conserved in yeast. Its expression at the RNA level in adult
human tissues is nearly ubiquitous, being relatively high in placenta,
prostate, ovary, and testis, but is not detectable in peripheral blood
leukocytes. Using fluorescence in situ hybridization on human
metaphase chromosomes and by analyzing rodent-human hybrids by Southern
blot hybridization and polymerase chain reaction amplification, we
mapped the human YAP gene to chromosome band 11q13, a region to which
the multiple endocrine neoplasia type 1 gene has been mapped.
Volume 270,
Number 24,
Issue of June 16, pp. 14733-14741, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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