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A rat homologue of chick ovalbumin upstream promoter
transcription factor I (COUP-TF I) was isolated using an expression
cloning method developed to iso-late neurite outgrowth inhibitors.
Overexpression of COUP-TF I in 3T3 fibroblasts resulted in reduction of
stable contact formation between neurites and transfected cells.
Additionally, COUP-TF I enhanced retinoic acid response
element-dependent reporter gene expression in 3T3 fibroblasts,
indicating that COUP-TF I can modulate transcriptional activation in
these cells. Our data suggest that COUP-TF transcription factors are
involved in the regulation of cell surface molecules during
neurogenesis.
Volume 270,
Number 25,
Issue of June 23, pp. 15066-15070, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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