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YY1 is a zinc finger transcription factor with unusual
structural and functional features. In a yeast two-hybrid screen, two
cellular proteins, cyclophilin A (CyPA) and FK506-binding protein 12
(FKBP12), interacted with YY1. These interactions are specific and also
occur in mammalian cells. Cyclosporin A and FK506 efficiently disrupt
the YY1-CyPA and YY1-FKBP12 interactions. Overexpression of human CyPA
and FKBP12 have different effects on YY1-regulated transcription with
these effects being promoter-dependent. These results suggest that
immunophilins may be mediators in the functional role of YY1.
Volume 270,
Number 25,
Issue of June 23, pp. 15187-15193, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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