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Volume 270, Number 27, Issue of July 07, pp. 15923-15925, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Cyclin A Links c-Myc to Adhesion-independent Cell Proliferation

John F. Barrett , Brian C. Lewis , Arthur T. Hoang , Rene J. Alvarez , Jr. , Chi V. Dang

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.




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