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Adhesion-independent growth is a neoplastic phenotype that is
inducible in Rat 1a fibroblasts by enforced MYC expression.
The c-Myc protein has been well characterized as a transcription
factor, yet the molecular basis of c-Myc-induced neoplastic
transformation has remained elusive. In this report, we demonstrate a
link between ectopic MYC expression, deregulated cyclin A
levels, and adhesion-independent growth.
Volume 270,
Number 27,
Issue of July 07, pp. 15923-15925, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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