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Granulocyte-macrophage colony-stimulating factor (GM-CSF) and
interleukin 3 (IL-3) stimulate the proliferation and maturation of
myeloid progenitor cells following interaction with heterodimeric
receptors that share a common
Volume 270,
Number 27,
Issue of July 07, pp. 15979-15983, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
subunit required for signal
transduction. Our previous studies have demonstrated that GM-CSF and
IL-3 activate signaling pathways which converge upon a cAMP response
element-binding protein (CREB)-binding site of the human immediate
early response gene (early growth response gene-1, egr-1)
promoter. Using electromobility supershift assays and antibodies
directed against CREB phosphorylated on serine 133, we show that CREB
is phosphorylated on serine 133 in response to GM-CSF or IL-3
stimulation. We demonstrate that phosphorylation of CREB on serine 133
substantially contributes to transcriptional activation of egr-1 in response to GM-CSF but not IL-3. These studies suggest that
phosphorylation of CREB may play different roles during signal
transduction, resulting in unique and overlapping biological functions
in myeloid cells.
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