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Volume 270, Number 27, Issue of July 07, pp. 16134-16139, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.

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Ji-Nan Zhang , James E. Wilks , Joseph J. Billadello

The B creatine kinase gene is regulated by an array of positive and negative cis-elements in the 5`-flanking DNA that function in both muscle and nonmuscle cells. In CC myogenic cells M and B creatine kinase mRNAs are coordinately up-regulated in the early stages of myogenesis and then undergo distinct regulatory programs. The B creatine kinase gene is down-regulated in the late stages of myogenesis as M creatine kinase becomes the predominant species in mature myotubes. Sequences between -92 and +80 of the B creatine kinase gene confer a regulated pattern of expression to chimeric plasmids that closely resembles the time course of expression of the endogenous B creatine kinase gene in CC cells undergoing differentiation. We show that sequences within the first exon of the B creatine kinase gene are important for the developmental regulation of the gene in CC cells and that these sequences bind a nuclear protein that shows a similar tissue-specific distribution and developmentally regulated expression to that of the endogenous B creatine kinase gene.

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