| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Expression of the gene encoding the mitochondrial fatty acid
Volume 270,
Number 27,
Issue of July 07, pp. 16308-16314, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
-oxidation enzyme, medium-chain acyl-CoA dehydrogenase (MCAD), is
regulated among tissues during development and in response to
alterations in substrate availability. To identify and characterize
cis-acting MCAD gene promoter regulatory elements and corresponding
transcription factors, DNA-protein binding studies and mammalian cell
transfection analyses were performed with human MCAD gene promoter
fragments. DNA:protein binding studies with nuclear protein extracts
prepared from hepatoma G2 cells, 3T3 fibroblasts, or Y-1 adrenal tumor
cells identified three sequences (nuclear receptor response element 1
or NRRE-1, NRRE-2, and NRRE-3) that bind orphan members of the
steroid/thyroid nuclear receptor superfamily including chicken
ovalbumin upstream promoter transcription factor and steroidogenic
factor 1. Sp1 binding sites (A-C) were identified in close
proximity to each of the NRREs. NRRE-3 conferred cell line-specific
transcriptional repression by interacting with chicken ovalbumin
upstream promoter transcription factor or activation via steroidogenic
factor 1. In contrast, the Sp1 binding site A behaved as a
transcriptional activator in all cell lines examined. We propose that
multiple nuclear receptor transcription factors interact with MCAD gene
promoter elements to differentially regulate transcription among a
variety of cell types.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Giguere Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors Endocr. Rev., October 1, 2008; 29(6): 677 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Schaeffer, A. R. Wende, C. J. Magee, J. R. Neilson, T. C. Leone, F. Chen, and D. P. Kelly Calcineurin and Calcium/Calmodulin-dependent Protein Kinase Activate Distinct Metabolic Gene Regulatory Programs in Cardiac Muscle J. Biol. Chem., September 17, 2004; 279(38): 39593 - 39603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Huss, R. P. Kopp, and D. P. Kelly Peroxisome Proliferator-activated Receptor Coactivator-1alpha (PGC-1alpha ) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-alpha and -gamma . IDENTIFICATION OF NOVEL LEUCINE-RICH INTERACTION MOTIF WITHIN PGC-1alpha J. Biol. Chem., October 18, 2002; 277(43): 40265 - 40274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rosenblatt-Velin, C. Montessuit, I. Papageorgiou, J. Terrand, and R. Lerch Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism Cardiovasc Res, December 1, 2001; 52(3): 407 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Kurtz, L. Tian, B. A. Gower, T. R. Nagy, C. A. Pinkert, and P. A. Wood Transgenic studies of fatty acid oxidation gene expression in nonobese diabetic mice J. Lipid Res., December 1, 2000; 41(12): 2063 - 2070. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. B. Vega, J. M. Huss, and D. P. Kelly The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor alpha in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes Mol. Cell. Biol., March 1, 2000; 20(5): 1868 - 1876. [Abstract] [Full Text]
|
|
|
|
|
|
E. Barnea and Y. Bergman Synergy of SF1 and RAR in Activation of Oct-3/4 Promoter J. Biol. Chem., February 25, 2000; 275(9): 6608 - 6619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Hunt, S. E. B. Nousiainen, M. K. Huttunen, K. E. Orii, L. T. Svensson, and S. E. H. Alexson Peroxisome Proliferator-induced Long Chain Acyl-CoA Thioesterases Comprise a Highly Conserved Novel Multi-gene Family Involved in Lipid Metabolism J. Biol. Chem., November 26, 1999; 274(48): 34317 - 34326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Orii, K. O. Orii, M. Souri, T. Orii, N. Kondo, T. Hashimoto, and T. Aoyama Genes for the Human Mitochondrial Trifunctional Protein alpha - and beta -Subunits Are Divergently Transcribed from a Common Promoter Region J. Biol. Chem., March 19, 1999; 274(12): 8077 - 8084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Qian, L. Kuo, Y.-T. Yu, and J. N. Rottman A Concise Promoter Region of the Heart Fatty Acid–Binding Protein Gene Dictates Tissue-Appropriate Expression Circ. Res., February 19, 1999; 84(3): 276 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Brandt, F. Djouadi, and D. P. Kelly Fatty Acids Activate Transcription of the Muscle Carnitine Palmitoyltransferase I Gene in Cardiac Myocytes via the Peroxisome Proliferator-activated Receptor alpha J. Biol. Chem., September 11, 1998; 273(37): 23786 - 23792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Petersenn, A. C. Rasch, M. Heyens, and H. M. Schulte Structure and Regulation of the Human Growth Hormone-Releasing Hormone Receptor Gene Mol. Endocrinol., February 1, 1998; 12(2): 233 - 247. [Abstract] [Full Text]
|
|
|
|
 |
|
 P Ruiz-Lozano, S. Smith, G Perkins, S. Kubalak, G. Boss, H. Sucov, R. Evans, and K. Chien Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos Development, January 2, 1998; 125(3): 533 - 544. [Abstract] [PDF]
|
|
|
|
|
|
S.-L. Li, A. J. Valente, S.-J. Zhao, and R. A. Clark PU.1 Is Essential for p47phox Promoter Activity in Myeloid Cells J. Biol. Chem., July 11, 1997; 272(28): 17802 - 17809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Sack, D. L. Disch, H. A. Rockman, and D. P. Kelly A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program PNAS, June 10, 1997; 94(12): 6438 - 6443. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
