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The cytokine signaling pathways that activate the Janus family
of tyrosine kinases (Jaks) and the ``signal transducers and
activators of transcription'' (Stats) have been well characterized
in mammalian systems. Work shown here provides evidence that an
analogous signaling pathway exists in Drosophila melanogaster.
Because many of the ligand-receptor pairs in Drosophila have
not been fully characterized, it was necessary to bypass the receptor
stimulation event that normally triggers intracellular Jak/Stat
activation. This was done by treating Drosophila Schneider 2
cells with vanadate/peroxide, which has been shown to closely mimic
some signaling events triggered by interferon
Volume 270,
Number 28,
Issue of July 14, pp. 16510-16513, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
, including the
activation of Jak1, Jak2, and the Stat1
protein. Evidence
presented here demonstrates that vanadate/peroxide can induce a
response region binding complex in Drosophila Schneider 2
cells. This complex contains two phosphoproteins of 100 and 150 kDa,
respectively, and shares many features with the
vanadate/peroxide-stimulated binding complex in the mammalian system.
Southern blot analysis of genomic DNA using the src homology
domain 2 (SH2) of Stat1
confirms the presence of a related gene in
the Drosophila genome.
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